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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleExtraction of indole alkaloids from Tabernaemontana catharinensis using supercritical CO2 plus ethanol: an evaluation of the process variables and the raw material originpt_BR
dc.contributor.authorPereira, CGpt_BR
dc.contributor.authorMarques, MOMpt_BR
dc.contributor.authorBarreto, ASpt_BR
dc.contributor.authorSiani, ACpt_BR
dc.contributor.authorFernandes, ECpt_BR
dc.contributor.authorMeireles, MAApt_BR
unicamp.author.emailmeireles@fea.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, FEA, DEA, LASEFI, BR-13083970 Campinas, SP, Brazil IAC, LPN, BR-13001970 Campinas, SP, Brazil IAC, Ctr Genet Biol Mol & Fitoquim, BR-13001970 Campinas, SP, Brazil Fiocruz MS, Inst Tecnol Farmacos, LQPN, BR-21041250 Rio De Janeiro, Brazilpt_BR
dc.subjectsupercritical extractionpt_BR
dc.subjectSFEpt_BR
dc.subjectcosolventpt_BR
dc.subjectindole alkaloidspt_BR
dc.subjecttabernaemontana catharinensispt_BR
dc.subjectLeishmaniasispt_BR
dc.subject.wosApocynaceaept_BR
dc.subject.wosRapdpt_BR
dc.description.abstractIndole alkaloids from Tabernaemontana catharinensis, collected from different places, were extracted using a mixture of supercritical CO2 plus ethanol. The effects of the process variables: temperature, pressure, solvent flow rate, and percentage of cosolvent on the total yield, chemical composition of the extract, and extraction kinetics were determined. The extracts were solvent-partitioned and their composition analyzed by TLC, GC-MS and H-1 and C-13 NMR. Voacangine and coronaridine were identified as the major compounds in the extracts; the individual alkaloids were quantified by GC-FID using external standard. At 250 bar and 45 degreesC the largest yield (1.29%) and the faster extraction rate were obtained; increasing the percentage of cosolvent improved the extraction rate as well as the yield. Employing an intermittent process consisting in six pressurization-depressurization steps appreciably reduced the total extraction time. (C) 2003 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofJournal Of Supercritical Fluidspt_BR
dc.relation.ispartofabbreviationJ. Supercrit. Fluidspt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2004pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationJournal Of Supercritical Fluids. Elsevier Science Bv, v. 30, n. 1, n. 51, n. 61, 2004.pt_BR
dc.language.isoenpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage51pt_BR
dc.description.lastpage61pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0896-8446pt_BR
dc.identifier.wosidWOS:000221710300005pt_BR
dc.identifier.doi10.1016/S0896-8446(03)00112-8pt_BR
dc.date.available2014-11-13T22:15:32Z
dc.date.available2015-11-26T17:11:50Z-
dc.date.accessioned2014-11-13T22:15:32Z
dc.date.accessioned2015-11-26T17:11:50Z-
dc.description.provenanceMade available in DSpace on 2014-11-13T22:15:32Z (GMT). No. of bitstreams: 1 WOS000221710300005.pdf: 160846 bytes, checksum: 760c52ad13cf260f7273feb1ac7150e4 (MD5) Previous issue date: 2004en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:11:50Z (GMT). No. of bitstreams: 2 WOS000221710300005.pdf: 160846 bytes, checksum: 760c52ad13cf260f7273feb1ac7150e4 (MD5) WOS000221710300005.pdf.txt: 39536 bytes, checksum: e1bdd6143a116899ad5a807a69ad2396 (MD5) Previous issue date: 2004en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66582pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/66582
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66582-
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