Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/66468
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleExpression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervixpt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorDerchain, SFpt_BR
dc.contributor.authorYoshida, Apt_BR
dc.contributor.authorVassallo, Jpt_BR
dc.contributor.authorPignataro, Fpt_BR
dc.contributor.authorDe Angelo Andrade, LALpt_BR
unicamp.author.emailsarian@terra.com.brpt_BR
unicamp.authorUniv Estadual Campinas, UNICAMP, Dept Pathol, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectMIB-1pt_BR
dc.subjectcervical intraepithelial neoplasiapt_BR
dc.subjectcancerpt_BR
dc.subjectcervixpt_BR
dc.subjectimmunohistochemistrypt_BR
dc.subject.wosIntraepithelial Neoplasiapt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosCarcinomapt_BR
dc.subject.wosImmunohistochemistrypt_BR
dc.subject.wosSurvivalpt_BR
dc.subject.wosCyclept_BR
dc.description.abstractObjectives. To assess the expression of cyclooxygenase (COX-2) and Ki67 in cervical squamous lesions in relation to disease severity and human papillomavirus (HPV) detection. Subjects and methods. For this cross-sectional study, 223 women subjected to diathermic conization of the cervix have been enrolled, between February 2001 and April 2004. All patients undertook pelvic examination, including colposcopy and collection of samples for Hybrid Capture II (HCII). Pathological assessment disclosed: 9 cases of normal epithelium/cervicitis, 33 CIN1, 28 CIN2, 146 CIN3 and 7 invasive squamous cell carcinomas. COX-2 and Ki67 protein expression was determined with immunohistochemistry. COX-2 immunoreactivity grading was based on the German ImmonoReactive score. The continuum percentage of positive cells was used for the assessment of nuclear Ki67 expression. Results. Expression of COX-2 did not correlate with disease severity and with Ki67 expression. The HPV detection rates did not differ significantly across COX-2 protein expression strata, ranging from negative to strong expression. Ki67 expression, however, was higher in the CIN3 group (P = 0.001) as compared to the specimens rendered as normal/cervicitis. Conclusions. COX-2 protein expression did not correlate with disease severity or Ki67 expression. (c) 2006 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofGynecologic Oncologypt_BR
dc.relation.ispartofabbreviationGynecol. Oncol.pt_BR
dc.publisher.citySan Diegopt_BR
dc.publisher.countryEUApt_BR
dc.publisherAcademic Press Inc Elsevier Sciencept_BR
dc.date.issued2006pt_BR
dc.date.monthofcirculationSEPpt_BR
dc.identifier.citationGynecologic Oncology. Academic Press Inc Elsevier Science, v. 102, n. 3, n. 537, n. 541, 2006.pt_BR
dc.language.isoenpt_BR
dc.description.volume102pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage537pt_BR
dc.description.lastpage541pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0090-8258pt_BR
dc.identifier.wosidWOS:000240871000023pt_BR
dc.identifier.doi10.1016/j.ygyno.2006.01.052pt_BR
dc.date.available2014-11-18T03:25:20Z
dc.date.available2015-11-26T16:50:20Z-
dc.date.accessioned2014-11-18T03:25:20Z
dc.date.accessioned2015-11-26T16:50:20Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T03:25:20Z (GMT). No. of bitstreams: 1 WOS000240871000023.pdf: 232901 bytes, checksum: 2d0b243f0a4a00ea142d4cf7a674aa89 (MD5) Previous issue date: 2006en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:50:20Z (GMT). No. of bitstreams: 2 WOS000240871000023.pdf: 232901 bytes, checksum: 2d0b243f0a4a00ea142d4cf7a674aa89 (MD5) WOS000240871000023.pdf.txt: 26254 bytes, checksum: 2018aa9b3d17f7bfb80dce314e8fb0a2 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66468pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/66468
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66468-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000240871000023.pdf227.44 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.