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Type: Artigo de periódico
Title: Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice
Author: da Silva, MA
Rafacho, BPM
Hiruma-Lima, CA
da Rocha, LRM
dos Santos, LC
Sannomiya, M
Souza-Brito, ARM
Vilegas, W
Abstract: Strychnos pseudoquina Sr. HiL.. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.
Subject: Strychnos pseudoquina
antiulcer activity
toxic activity
Country: Japão
Editor: Pharmaceutical Soc Japan
Citation: Chemical & Pharmaceutical Bulletin. Pharmaceutical Soc Japan, v. 53, n. 8, n. 881, n. 885, 2005.
Rights: aberto
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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