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Type: Artigo de periódico
Title: Endocervical glandular cell abnormalities in conventional cervical smears: evaluation of the performance of cytomorphological criteria and HPV testing in predicting neoplasia
Author: Rabelo-Santos, SH
Derchain, SFM
Westin, MCDA
Angelo-Andrade, LAL
Sarian, LOZ
Oliveira, ERZM
Morais, SS
Zeferino, LC
Abstract: Objective: To analyse the correlation between cytomorphological criteria in smears with atypical glandular cells (AGC) or adenocarcinoma in situ (AIS) and human papillomavirus (HPV) reflex test results with different neoplastic histological diagnoses, particularly to distinguish between glandular and squamous neoplasia. Methods: A series of 155 women with glandular abnormalities in their conventional cervical smears was included: 106 with AGC, 35 with AGC associated with high-grade squamous intraepithelial lesion (HSIL) and 14 with AIS. Two reviewers evaluated 35 cytomorphological criteria and hybrid capture II (HCII) was performed in all cases. Colposcopy was carried out in all cases and biopsy in 126/155. For statistical purposes, predictive values and odds ratio (OR) were calculated, followed by chi-square automatic interaction detection. Results: Histology detected 56 cases of squamous and 17 of glandular intraepithelial or invasive neoplasia. Predictive values of the papillary groups and feathering criteria for glandular neoplasia were, respectively, 80.0% and 73.3%. Feathering was the criterion with the highest OR for distinguishing glandular from squamous neoplasia and also for distinguishing between glandular and non-neoplastic diagnosis. Rosettes and pseudostratified strips did not perform as well. Multivariant Classification and Regression Trees analysis identified feathering as the best criterion for distinguishing between glandular, squamous and non-neoplastic diagnoses regardless of HPV status. Conclusions: Feathering was the best criterion for predicting glandular neoplasia.
Subject: cervix
atypical glandular cells
adenocarcinoma in situ
squamous neoplasia
glandular neoplasia
conventional cytology
cervical intraepithelial neoplasia
Country: Inglaterra
Editor: Blackwell Publishing
Citation: Cytopathology. Blackwell Publishing, v. 19, n. 1, n. 34, n. 43, 2008.
Rights: fechado
Identifier DOI: 10.1111/j.1365-2303.2007.00466.x
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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