Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63638
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEarly total white blood cell recovery is a predictor of low number of apheresis and good CD34(+) cell yieldpt_BR
dc.contributor.authorMarques, JFCpt_BR
dc.contributor.authorVigorito, ACpt_BR
dc.contributor.authorAranha, FJPpt_BR
dc.contributor.authorLorand-Metze, Ipt_BR
dc.contributor.authorMiranda, ECMpt_BR
dc.contributor.authorLima, ECpt_BR
dc.contributor.authorValbonesi, Mpt_BR
dc.contributor.authorSantini, Gpt_BR
dc.contributor.authorDe Souza, CApt_BR
unicamp.authorUniv Estadual Campinas, UNICAMP, Haemoctr, Haematol & Blood Transfus Ctr, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectperipheral blood progenitor cell mobilisationpt_BR
dc.subjectapheresispt_BR
dc.subjecthaematological malignanciespt_BR
dc.subjectchemotherapy and radiotherapypt_BR
dc.subject.wosHigh-dose Cyclophosphamidept_BR
dc.subject.wosColony-stimulating Factorpt_BR
dc.subject.wosHematopoietic Stem-cellspt_BR
dc.subject.wosNon-hodgkins-lymphomapt_BR
dc.subject.wosFactor Rhgm-csfpt_BR
dc.subject.wosPeripheral-bloodpt_BR
dc.subject.wosProgenitor Cellspt_BR
dc.subject.wosMultiple-myelomapt_BR
dc.subject.wosBone-marrowpt_BR
dc.subject.wosAutologous Transplantationpt_BR
dc.description.abstractObjective. We analysed peripheral blood progenitor cell (PBPC) mobilisation and collection in order to assess the main factors related to CD34(+) cell yields in patients affected by haematological malignancies. Patients find Methods. The features of CD34(+) cell mobilisation of patients with haematological malignancies that underwent autologous bone marrow transplantation were examined. Mobilisation chemotherapy consisted mainly of cyclophosphamide (CY) 4 or 7 g/m(2) followed by growth factors. Leukapheresis was started when the WBC counts reached 1.0x10(9)/1 with the aim to collect at least 5x10(6) CD34(+) cells/kg body weight. The aphereses were performed on continuous-flow blood cell separators. The analysed variables were: age, diagnosis, CT mobilisation regimen, type of growth factor, number of previous CT lines, prior radiotherapy, days for WBC recovery and number of aphereses procedures to achieve the target of CD34(+) cells. Results, There were 41 consecutive patients (26 M/15 F): 21 non-Hodgkin's lymphoma (NHL), 15 Hodgkin's disease (HD), two chronic myeloid leukaemia (CML) and three multiple myeloma (MM). Eleven patients could not collect the proposed threshold of CD34(+) cells. CY 4 mobilised patients recovered WBC counts in less days (P=0.03). By ANOVA, the days to WBC recovery had a linear function of the predictors "number of aphereses" and "type of mobilisation CT" (coefficients: 0.86 and 0.95, respectively). For the number of aphereses and WBC recovery after CT mobilisation, we obtained a correlation coefficient of 0.36 (P = 0.02). Conclusion. This study shows that it is feasible to mobilise and collect PBPC in patients previously treated with CT with or without RT. There was a linear correlation between the days for WBC recovery and the number of aphereses needed to collect the target number of CD34(+) cells. The study suggests that early WBC recovery, using mainly CY 4 mobilisation chemotherapy, is an important predictor of a low number of aphereses to achieve a good CD34(+) yield. (C) 2000 Elsevier Science Ltd. All rights reserved.pt
dc.relation.ispartofTransfusion Sciencept_BR
dc.relation.ispartofabbreviationTransfus. Sci.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2000pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationTransfusion Science. Pergamon-elsevier Science Ltd, v. 23, n. 2, n. 91, n. 100, 2000.pt_BR
dc.language.isoenpt_BR
dc.description.volume23pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage91pt_BR
dc.description.lastpage100pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0955-3886pt_BR
dc.identifier.wosidWOS:000165066500004pt_BR
dc.identifier.doi10.1016/S0955-3886(00)00072-2pt_BR
dc.date.available2014-12-02T16:31:19Z
dc.date.available2015-11-26T17:42:22Z-
dc.date.accessioned2014-12-02T16:31:19Z
dc.date.accessioned2015-11-26T17:42:22Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:31:19Z (GMT). No. of bitstreams: 1 WOS000165066500004.pdf: 185741 bytes, checksum: 47f3dba0cdd96a0e4a689cd8a9aa7349 (MD5) Previous issue date: 2000en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:42:22Z (GMT). No. of bitstreams: 2 WOS000165066500004.pdf: 185741 bytes, checksum: 47f3dba0cdd96a0e4a689cd8a9aa7349 (MD5) WOS000165066500004.pdf.txt: 36758 bytes, checksum: 8863883631561cff5f25f78a630bddc7 (MD5) Previous issue date: 2000en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63638pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/63638
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63638-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000165066500004.pdf181.39 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.