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Type: Artigo de periódico
Title: Brazilian Experience Using High-Dose Sequential Chemotherapy Followed by Autologous Hematopoietic Stem Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma
Author: Duarte, BKL
Valente, I
Vigorito, AC
Aranha, FJP
Oliveira-Duarte, G
Miranda, ECM
Lorand-Metze, I
Pagnano, KB
Delamain, M
Marques, JF
Brandalise, SR
Nucci, M
De Souza, CA
Abstract: Purpose: We evaluate the effectiveness and toxicity of high-dose sequential chemotherapy (HDS) as salvage therapy in patients with advanced-stage Hodgkin lymphoma. Patients and Methods: We performed a retrospective analysis on 77 patients receiving HDS between 1998 and 2006. Patients enrolled were in disease progression or relapsed disease, or did not achieve a complete remission after first-line treatment. HDS consisted of the sequential administration of cyclophosphamide and granulocyte colony-stimulating factor with stem cell harvesting, followed by methotrexate plus vincristine and etoposide. Results: The majority of patients had stage III/IV (64%) and B symptoms (71.4%). Disease status improvement after HDS was observed in 24 of 57 patients (42%) previously in disease progression or relapse. HDS-related deaths occurred in 8 of 77 patients (10.4%). Four patients (5.2%) developed acute myeloid leukemia/myelodysplastic syndrome. Overall, disease-free and progression-free survival was 27%, 57%, and 25%, respectively. Conclusion: Despite the treatment-related mortality, HDS is feasible, with satisfactory response rates, even in patients with poor prognosis.
Subject: Autologous stem cell transplantation
High-dose cyclophosphamide
Epstein-Barr virus
Hodgkin's lymphoma
Country: EUA
Editor: Cig Media Group, Lp
Citation: Clinical Lymphoma & Myeloma. Cig Media Group, Lp, v. 9, n. 6, n. 449, n. 454, 2009.
Rights: fechado
Identifier DOI: 10.3816/CLM.2009.n.088
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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