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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCarbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performancept_BR
dc.contributor.authorde Oliveira, SLpt_BR
dc.contributor.authorDiniz, DBpt_BR
dc.contributor.authorAmaya-Farfan, Jpt_BR
unicamp.authorState Univ Campinas, Dept Food & Nutr, BR-13083970 Campinas, SP, Brazil State Univ Ceara, Dept Nutr, Fortaleza, Ceara, Brazil Fed Univ Alagoas, Dept Nutr, Maceio, AL, Brazilpt_BR
dc.subjectenergy restrictionpt_BR
dc.subjectvitamin Ept_BR
dc.subjectoxidative stresspt_BR
dc.subjectexercisept_BR
dc.subject.wosVitamin-ept_BR
dc.subject.wosLipid-peroxidationpt_BR
dc.subject.wosDietary Restrictionpt_BR
dc.subject.wosAntioxidant Statuspt_BR
dc.subject.wosSkeletal-musclept_BR
dc.subject.wosExercised Ratspt_BR
dc.subject.wosMembrane Fluiditypt_BR
dc.subject.wosAlpha-tocopherolpt_BR
dc.subject.wosFood Restrictionpt_BR
dc.subject.wosDna-damagept_BR
dc.description.abstractChronic energy restriction, alpha-tocopherol supplementation and their interaction with exhaustive exercise were investigated. Eleven-week-old male Wistar rats (n 6 x 10) were fed either a control (C), a 30 % carbohydrate-energy-restricted control (R) or an alpha-tocopherol-supplemented (S) diet for 5 months. The animals in each diet were divided into exercised (E) and non-exercised (NE) groups. Before killing, the exercised rats were required to run to exhaustion (39 (SE 6), 69 (SE, 11) and 18 (SE 2) min for the C, R and S groups, respectively). Lipid peroxidation (thiobarbituric acid-reactive substances; TBARS), protein damage (reactive carbonyls) and alpha-tocopherol were determined in gastrocnemius, liver, brain and/or plasma. There was no difference in lipid peroxidation between the R and C groups, but in liver and muscle peroxidation appeared significantly lower in the S than the other two diets. TBARS in the brain were similar in all groups. On the other hand, reactive carbonyls showed that both the R and S diets reduced protein damage in the brain, while exhaustive exercise increased it. For liver and muscle, however, reactive carbonyl levels were similar in all groups. alpha-Tocopherol supplementation increased the vitamin concentrations in liver, muscle and plasma, but exercise decreased them in plasma and brain. Carbohydrate-energy restriction increased (P=0.0025) resistance to exhaustive exercise considerably without depleting stores of alpha-tocopherol or exacerbating oxidative damage in monitored tissues. It is concluded that while exhaustive exercise promotes a tissue-specific oxidative damage detectable only in brain proteins, both experimental diets tended to ameliorate this condition.pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofBritish Journal Of Nutritionpt_BR
dc.relation.ispartofabbreviationBr. J. Nutr.pt_BR
dc.publisher.cityWallingfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherC A B I Publishingpt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationBritish Journal Of Nutrition. C A B I Publishing, v. 89, n. 1, n. 89, n. 96, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume89pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage89pt_BR
dc.description.lastpage96pt_BR
dc.rightsembargopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0007-1145pt_BR
dc.identifier.wosidWOS:000180648600011pt_BR
dc.identifier.doi10.1079/BJN2002749pt_BR
dc.date.available2014-11-14T20:53:00Z
dc.date.available2015-11-26T16:08:28Z-
dc.date.accessioned2014-11-14T20:53:00Z
dc.date.accessioned2015-11-26T16:08:28Z-
dc.description.provenanceMade available in DSpace on 2014-11-14T20:53:00Z (GMT). No. of bitstreams: 1 WOS000180648600011.pdf: 128882 bytes, checksum: 2d2b51d121cb08bb46e8536b08f1658f (MD5) Previous issue date: 2003en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:08:28Z (GMT). No. of bitstreams: 2 WOS000180648600011.pdf: 128882 bytes, checksum: 2d2b51d121cb08bb46e8536b08f1658f (MD5) WOS000180648600011.pdf.txt: 42127 bytes, checksum: 1710c022cdc3ff715a69d85669bf6b45 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63143pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/63143
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63143-
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