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Type: Artigo de periódico
Title: Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-L-cysteine
Author: Abbehausen, C
Heinrich, TA
Abrao, EP
Costa-Neto, CM
Lustri, WR
Formiga, ALB
Corbi, PP
Abstract: A new silver(I) complex with N-acetyl-t-cysteine (NAC) of composition AgC(5)H(8)NO(3)S center dot H(2)O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state (13)C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag-NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl-t-cysteine (Ag-NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coil and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for evaluation of a potential cytotoxic effect of Ag-NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a significant cytotoxic activity, inducing 80% of cell death at a concentration of 200 mu mol L(-1). (C) 2010 Elsevier Ltd. All rights reserved.
Subject: Silver(I)
Infrared spectroscopy
NMR spectroscopy
Antibacterial activity
Antitumoral assay
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Polyhedron. Pergamon-elsevier Science Ltd, v. 30, n. 4, n. 579, n. 583, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.poly.2010.11.025
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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