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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCharacterization of the inclusion complex ropivacaine: beta-cyclodextrinpt_BR
dc.contributor.authorFraceto, LFpt_BR
dc.contributor.authorGoncalves, MMpt_BR
dc.contributor.authorMoraes, CMpt_BR
dc.contributor.authorde Araujo, DRpt_BR
dc.contributor.authorZanella, Lpt_BR
dc.contributor.authorde Paula, Ept_BR
dc.contributor.authorPertinhez, TDApt_BR
unicamp.author.emailleonardo@sorocaba.unesp.brpt_BR
unicamp.authorUniv Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sao Paulo, Brazil Univ Sorocaba, BR-18023000 Sao Paulo, Brazil Univ Estadual Campinas, Inst Biol, Dept Bioquim, BR-13083970 Campinas, SP, Brazil Univ Parma, Dept Expt Med, I-43100 Parma, Italypt_BR
dc.subjectropivacamept_BR
dc.subjectcyclodextrinpt_BR
dc.subjectNMRpt_BR
dc.subject.wosLocal-anestheticspt_BR
dc.subject.wosNmr-spectroscopypt_BR
dc.subject.wosPhospholipid-bilayerspt_BR
dc.subject.wosGamma-cyclodextrinpt_BR
dc.subject.wosAqueous-solutionpt_BR
dc.subject.wosH-1-nmrpt_BR
dc.subject.wosDrugspt_BR
dc.subject.wosAlphapt_BR
dc.subject.wosBupivacainept_BR
dc.subject.wosResolutionpt_BR
dc.description.abstractRopivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.pt
dc.relation.ispartofQuimica Novapt_BR
dc.relation.ispartofabbreviationQuim. Novapt_BR
dc.publisher.citySao Paulopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSoc Brasileira Quimicapt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationSEP-OCTpt_BR
dc.identifier.citationQuimica Nova. Soc Brasileira Quimica, v. 30, n. 5, n. 1203, n. 1207, 2007.pt_BR
dc.language.isoptpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage1203pt_BR
dc.description.lastpage1207pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.wosidWOS:000249501000028pt_BR
dc.identifier.doi10.1590/S0100-40422007000500028pt_BR
dc.date.available2014-11-18T14:49:05Z
dc.date.available2015-11-26T16:56:00Z-
dc.date.accessioned2014-11-18T14:49:05Z
dc.date.accessioned2015-11-26T16:56:00Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T14:49:05Z (GMT). No. of bitstreams: 1 WOS000249501000028.pdf: 374745 bytes, checksum: a9063a55f3da9cef21ac1cf2089e14a1 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:56:00Z (GMT). No. of bitstreams: 2 WOS000249501000028.pdf: 374745 bytes, checksum: a9063a55f3da9cef21ac1cf2089e14a1 (MD5) WOS000249501000028.pdf.txt: 23611 bytes, checksum: 5443ea391531e33f28162a5b020d6105 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62905pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/62905
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62905-
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