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Type: Artigo de periódico
Title: Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy
Author: Damasceno, A
Franca, MC
Cendes, F
Nucci, A
Abstract: Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN, the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. Objective: To evaluate cerebellar atrophy in SN. Method: We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls. Results: Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN. Conclusion: Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients.
Subject: cerebellar atrophy
cerebellar volume reduction
magnetic resonance imaging
sensory neuron disease
sensory neuronopathy
Country: Brasil
Editor: Assoc Arquivos Neuro- Psiquiatria
Citation: Arquivos De Neuro-psiquiatria. Assoc Arquivos Neuro- Psiquiatria, v. 69, n. 4, n. 602, n. 606, 2011.
Rights: aberto
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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