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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDisodium cromoglycate protects dystrophin-deficient muscle fibers from leakinesspt_BR
dc.contributor.authorMarques, MJpt_BR
dc.contributor.authorMachado, RVpt_BR
dc.contributor.authorMinatel, Ept_BR
dc.contributor.authorNeto, HSpt_BR
unicamp.author.emailmarques@unicamp.brpt_BR
unicamp.authorMarques, Maria Julia Machado, Rafael Ventura Minatel, Elaine Neto, Humberto Santo Univ Estadual Campinas, Inst Biol, Dept Anat, BR-13083970 Sao Paulo, Brazilpt_BR
dc.subject.wosDuchenne Muscular-dystrophypt_BR
dc.subject.wosMast-cell Degranulationpt_BR
dc.subject.wosMdx Micept_BR
dc.subject.wosSkeletal-musclept_BR
dc.subject.wosReduces Necrosispt_BR
dc.subject.wosEvans Bluept_BR
dc.subject.wosIn-vivopt_BR
dc.subject.wosMousept_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosDamagept_BR
dc.description.abstractIn dystrophin-deficient fibers of mdx mice and in Duchenne dystrophy, the lack of dystrophin leads to sarcolemma breakdown and muscle degeneration. We verified that cromolyn, a mast-cell stabilizer agent, stabilized dystrophic muscle fibers using Evans blue dye as a marker of sarcolemma leakiness. Mdx mice (n = 8; 14 days of age) received daily intraperitoneal injections of cromolyn (50 mg/kg body weight) for 15 days. Untreated mdx mice (n = 8) were injected with saline. Cryostat cross-sections of the sternomastoid, tibialis anterior, and diaphragm muscles were stained with hematoxylin and eosin. Cromolyn dramatically reduced Evans blue dye-positive fibers in all muscles (P < 0.05; Student's t-test) and led to a significant increase in the percentage of fibers with peripheral nuclei. This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin.pt
dc.relation.ispartofMuscle & Nervept_BR
dc.relation.ispartofabbreviationMuscle Nervept_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherJohn Wiley & Sons Incpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationMuscle & Nerve. John Wiley & Sons Inc, v. 37, n. 1, n. 61, n. 67, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume37pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage61pt_BR
dc.description.lastpage67pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0148-639Xpt_BR
dc.identifier.wosidWOS:000252114200009pt_BR
dc.identifier.doi10.1002/mus.20892pt_BR
dc.date.available2014-07-30T14:50:34Z
dc.date.available2015-11-26T16:31:42Z-
dc.date.accessioned2014-07-30T14:50:34Z
dc.date.accessioned2015-11-26T16:31:42Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:50:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:31:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62510
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62510-
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