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Type: Artigo de periódico
Title: Determination and Validation of Nimesulide in Pharmaceutical Formulation by Near Infrared Spectroscopy
Author: Rocha, WFC
Rosa, AL
Martins, JA
Poppi, RJ
Abstract: The determination of nimesulide in pharmaceutical formulation in the range of 10.38 to 39.47% m/m using near infrared spectroscopy and multivariate calibration based on partial least squares (PLS) and net analyte signal (NAS) was studied and validated by establishing its figures of merit. Suitable results were obtained, with limit of detection of 0.61%, limit quantification of 2.03%, accuracy estimated as root mean square error of prediction (RMSEP) of 1.05%, mean selectivity of 0.006, sensitivity of 0.004%, inverse analytical sensitivity of (0.20%)(-1) and signal-to-noise ratio of 181. In addition, it was obtained relative errors lower than 10% that are acceptable values for quality control of this drug. These results indicate that the proposed method can be used in pharmaceutical industries as an alternative to standard analytical procedures.
Subject: near-infrared spectroscopy
figures of merit
net analyte signal
Country: Brasil
Editor: Soc Brasileira Quimica
Citation: Journal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 21, n. 10, n. 1929, n. 1936, 2010.
Rights: aberto
Identifier DOI: 10.1590/S0103-50532010001000019
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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