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Type: Artigo de periódico
Title: Detection of high-risk human papillomavirus (HPV) DNA by hybrid capture II in women referred due to atypical glandular cells in the primary screening
Author: Olivera, ERZM
Derchain, SFM
Rabelo-Santos, SH
Westin, MCA
Zeferino, LC
Campos, EA
Syrjanen, KJ
Abstract: We assessed the detection of high-risk human papillomavirus DNA (HPV-DNA) in women examined by a second Pap smear due to atypical glandular cells (AGC) detected in their screening Pap smear. In 91 women included in the study, a second Pap smear was taken and HPV-DNA test was peformed using Hybrid Capture H (HC II). The second Pap smear showed no abnormalities in 28 (31%) cases, ACG in 17 (19%) cases, and high-grade squamous intraepithelial lesions (HSIL) or worse in 24 (26%). HC 11 test was positive in 36% of the cases. Considering the second Pap smear diagnosis, HPV-DNA was detected in 87% of the women with HSIL, 100% of women with in situ adenocarcinoma, and only, in 11% of the women with no abnormalities. The use of the second Pap smear combined with HPV-DNA may improve the management of women with AGC in the primary screening. (C) 2004 Wiley-Liss, Inc.
Subject: atypical glandular cells
adenocarcinoma in situ
human papillomavirus
hybrid capture II
Bethesda system
Country: EUA
Editor: Wiley-liss
Citation: Diagnostic Cytopathology. Wiley-liss, v. 31, n. 1, n. 19, n. 22, 2004.
Rights: fechado
Identifier DOI: 10.1002/dc.20049
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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