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Type: Artigo de periódico
Title: Platelet glycoprotein Ib alpha polymorphisms modulate the risk for myocardial infarction
Author: Ozelo, MC
Origa, AF
Aranha, FJR
Mansur, AR
Annichino-Bizzacchi, JM
Costa, FF
Pollak, ES
Arruda, PR
Abstract: Platelet glycoprotein Iba (GPIba) gene polymorphisms have been reported to affect the risk of developing coronary heart disease. Here, within the GPIba gene, we determine the association between the variable number of tandem repeats (VNTR), the -5C/T Kozak sequence dimorphism, and the human platelet antigen (HPA)-2 polymorphisms with occurrence of myocardial infarction (MI). Patients (n= 180) presenting survivors of MI were compared to 180 controls matched by age, gender, and race. Carriers of VNTR-CD genotype had a 2-fold higher risk for MI compared to controls.The prevalence of VNTR-BC was lower among patients than among controls (P=.007). These data are in agreement with recent reports of increased plug formation by human platelets containing VNTR-CD but no other VNTR genotypes. Among patients, the number of vessels severely occluded was greater among carriers of the D-allele (P=.O 19) or VNTR-CD (P=.026) and lower among carriers of the C-allele (P=.003) or VNTR-CC (P=.0009) compared to non-carriers of these alleles. No influence was seen with the Kozak or HPA-2 polymorphisms. Determination of VNTR of the GPIba gene may prove useful for identifying high-risk individuals for MI.
Subject: arterial disease
coronary heart disease
myocardial infarction
platelet glycoprotein Ib alpha
polymorphism VNTR
Country: Alemanha
Editor: Schattauer Gmbh-verlag Medizin Naturwissenschaften
Citation: Thrombosis And Haemostasis. Schattauer Gmbh-verlag Medizin Naturwissenschaften, v. 92, n. 2, n. 384, n. 386, 2004.
Rights: fechado
Identifier DOI: 10.1160/TH03-12-0744
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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