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Type: Artigo de periódico
Title: Plasma glucose regulation and insulin secretion in hypertriglyceridemic mice
Author: Amaral, MEC
Oliveira, HCF
Carneiro, EM
Delghingaro-Augusto, V
Vieira, EC
Berti, JA
Boschero, AC
Abstract: In this study, we examined glucose homeostasis and insulin secretion in transgenic mice overexpressing the human apolipoprotein CIII gene (apo CIII tg). These mice have elevated plasma levels of triglycerides, FFA and cholesterol compared to control mice. The body weight, plasma glucose, and insulin levels, glucose disappearance rates, areas under the ipGTT curve for adult (4-8 mo. old) and aged (20-24 mo. old) apo CIII tg mice and the determination of insulin during the ipGTT were riot different from those of control mice. However, an additional elevation of plasma FFA by treatment with heparin for 2-4h impaired the ipGTT responses in apo CIII tg mice compared to saline-treated mice. The glucose disappearance rate in heparin-treated transgenic mice was slightly lower than in heparin-treated controls. Glucose (22.2 mmol/l) stimulated insulin secretion in isolated islets to the same extent in saline-treated control and apo CIII tg mice. in islets from heparin-treated apo CIII tg mice, the insulin secretion at 2.8 and 22.2 mmol glucose/l was lower than in heparin-treated control mice. In conclusion, hypertriglyceridemia per se or a mild elevation in FFA did not affect insulin secretion or insulin resistance in adult or aged apo CIII tg mice. Nonetheless, an additional elevation of FFA induced by heparin in hypertriglyceridemic mice impaired the ipGTT by reducing insulin secretion.
Subject: glucose homeostasis
insulin secretion
apolipoprotein CIII
transgenic mice
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Citation: Hormone And Metabolic Research. Georg Thieme Verlag Kg, v. 34, n. 1, n. 21, n. 26, 2002.
Rights: aberto
Identifier DOI: 10.1055/s-2002-19962
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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