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|Title:||Plasma and salivary amoxicillin concentrations and effect against oral microorganisms|
Ruenis, A. P. D. B.
Motta, R. H. L.
Baglie, R. C. C.
Franco, G. C. N.
Franco, L. M.
Rosalen, P. L.
Groppo, F. C.
|Abstract:||Plasma and salivary amoxicillin (AMO) concentrations were quantified following a single oral dose (875 mg) of two formulations of AMO (Amoxicillin-EMS Sigma Pharma and Amoxil BID 875 mg). In addition, the effect of amoxicillin against oral microorganisms was accessed. The open, randomized, two-period crossover study was carried out in 20 volunteers. Saliva and blood samples were collected at 0, 0.5, 1, 2, 4, 8 and 12 h after drug administration, and quantified using HPLC-ESI-MS and HPLC, respectively. Streptococci counts, anaerobe counts and total microorganism counts were obtained. No differences were observed between forinulations (p > 0.05) in the plasma and salivary AMO concentrations and the pharmacokinetic parameters (C-max, t(max), AUC(0_8), and AUC(0-infinity)) also showed no statistically significant differences between formulations (p > 0.05). Microorganism counts for the two formulations at all sampling times dd not differ (p > 0.05) but all microorganism counts at 60 min post-dose showed a significant decrease (p < 0.05). Amoxicillin was effective in reducing oral microorganism levels up to 12 h post-dose.|
|Citation:||International Journal Of Clinical Pharmacology And Therapeutics. Dustri-verlag Dr Karl Feistle, v. 45, n. 10, n. 556, n. 562, 2007.|
|Appears in Collections:||FOP - Artigos e Outros Documentos|
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