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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleP53 expression as a predictor of recurrence in cervical squamous cell carcinomapt_BR
dc.contributor.authorBrenna, SMFpt_BR
dc.contributor.authorZeferino, LCpt_BR
dc.contributor.authorPinto, GApt_BR
dc.contributor.authorSouza, RApt_BR
dc.contributor.authorAndrade, LALpt_BR
dc.contributor.authorVassalo, Jpt_BR
dc.contributor.authorMartinez, EZpt_BR
dc.contributor.authorSyrjanen, KJpt_BR
unicamp.authorMatern Hosp Leonor Mendes de Barros, Hlth State Secretariat, BR-03015000 Sao Paulo, Brazil State Univ Campinas, Sch Med Sci, Expt Lab Pathol, Campinas, SP, Brazil Ist Super Sanita, Epidemiol & Biostat Lab, Unit Citopathol, I-00161 Rome, Italypt_BR
dc.subjectcervical cancerpt_BR
dc.subjectp53pt_BR
dc.subjectprognosispt_BR
dc.subjecttumor suppressor genept_BR
dc.subject.wosUterine Cervixpt_BR
dc.subject.wosHuman-papillomaviruspt_BR
dc.subject.wosPrognostic-significancept_BR
dc.subject.wosProtein Expressionpt_BR
dc.subject.wosRadiation-therapypt_BR
dc.subject.wosStage Ibpt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosAdenocarcinomapt_BR
dc.subject.wosPolymorphismpt_BR
dc.description.abstractP53 protein function is frequently down-regulated in cervical cancer by complexing with human papillomavirus (HPV) E6 protein, leading to degradation of p53, genomic instability, and mutations. Results are controversial, however, on the prognostic value of p53 protein expression in cervical cancer. In this study, a cohort of 220 Brazilian women with FIGO stage IB-III cervical squamous cell carcinoma (SCC), followed for 5 years, was analyzed for p53 protein expression using immunohistochemistry. The disease-free survival (DFS) and relapse rate were analyzed using univariate (Kaplan-Meier) and multivariable (Cox's proportional hazards model) survival analyses. P53 protein expression was detected in 35% of the patients, including 21% in stage I, 28% in stage II and 51% in stage III of disease. Of 220 women, only 116 completed one of the treatment options standardized by FIGO within 120 days. There was a higher risk of relapse in stage II and III disease, that was not modified by p53 positivity; HR 3.0 (1.3-6.5) to stage II and HR 4.0 (1.9-8.5) to stage III. The multivariate analysis evidenced that p53 expression is not an independent factor exceeding the power of FIGO stage as the single most important determinant of the hazards for disease relapse.pt
dc.relation.ispartofInternational Journal Of Gynecological Cancerpt_BR
dc.relation.ispartofabbreviationInt. J. Gynecol. Cancerpt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherBlackwell Publishing Incpt_BR
dc.date.issued2002pt_BR
dc.date.monthofcirculationMAY-JUNpt_BR
dc.identifier.citationInternational Journal Of Gynecological Cancer. Blackwell Publishing Inc, v. 12, n. 3, n. 299, n. 303, 2002.pt_BR
dc.language.isoenpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage299pt_BR
dc.description.lastpage303pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1048-891Xpt_BR
dc.identifier.wosidWOS:000176131400010pt_BR
dc.identifier.doi10.1046/j.1525-1438.2002.01097.xpt_BR
dc.date.available2014-11-19T04:37:42Z
dc.date.available2015-11-26T17:57:30Z-
dc.date.accessioned2014-11-19T04:37:42Z
dc.date.accessioned2015-11-26T17:57:30Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T04:37:42Z (GMT). No. of bitstreams: 1 WOS000176131400010.pdf: 177882 bytes, checksum: e4690e6f9ec7f22e9640cc1e6daa8cae (MD5) Previous issue date: 2002en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:57:30Z (GMT). No. of bitstreams: 2 WOS000176131400010.pdf: 177882 bytes, checksum: e4690e6f9ec7f22e9640cc1e6daa8cae (MD5) WOS000176131400010.pdf.txt: 22478 bytes, checksum: eab4601342d80ac764073629fb2e17bd (MD5) Previous issue date: 2002en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58972pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/58972
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58972-
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