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Type: Artigo de periódico
Author: Franca, MC
D'Abreu, A
Nucci, A
Cendes, F
Lopes-Cendes, I
Abstract: Peripheral neuropathy (PN) has long been recognized in Machado-Joseph disease (MJD), but its natural history is an unsettled issue. Therefore, we prospectively assessed 40 with MJD for 13 months with nerve conduction (NC) studies and the revised total neuropathy score (TNSr) to study the progression of PN. There was no significant change in the TNSr score over the follow-up period. In contrast, the average sural sensory nerve action potential (SNAP) amplitude decreased significantly over the same interval from a mean of 13.2 mu V to 9.8 mu V (P < 0.001). There was an inverse correlation between the change in the sural SNAP amplitude and the length of the CAG triplet repeat expansion (r = 0.574, P < 0.001). The reduction in the mean sural SNAP amplitude also correlated with progression of ataxia. This indicates that PN progresses faster in individuals with larger (CAG)(n) expansions, and nerve conduction studies may be useful to study disease progression in MJD. Muscle Nerve 40:1012-1018, 2009
Subject: Machado-Joseph disease
peripheral neuropathy
spinocerebellar ataxia type 3
electrophysiologic studies
axonal neuropathy
nerve conduction studies
natural history
Country: EUA
Editor: John Wiley & Sons Inc
Citation: Muscle & Nerve. John Wiley & Sons Inc, v. 40, n. 6, n. 1012, n. 1018, 2009.
Rights: fechado
Identifier DOI: 10.1002/mus.21396
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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