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Type: Artigo de periódico
Title: Cytokeratin expression in initial oral mucositis of head and neck irradiated patients
Author: Bonan, PRF
Kaminagakura, E
Pires, FR
Vargas, PA
de Almeida, OP
Abstract: Objective. The aim of this work was to study cytokeratin (Ck) expression in initial radiation-induced oral mucositis. Study design. Eleven cases of initial radiomucositis of the buccal mucosa and 9 normal specimens were immunostained for Ck 1, 5, 6, 7, 8, 10, 14, 16, 18, and 19 by immunoperoxidase method. Results. Expression of Ck 1, 6, 10, and 16 was stronger in mucositis than in normal mucosa. Ck 7, 8, and 18 were negative for both control and study groups. Ck 5, 13, and 14 were positive for both groups, nevertheless suprabasal staining for Ck 14 was more evident in mucositis than in the control group. Sporadic staining for Ck 19 was observed in 1 case of mucositis and in 2 controls. Conclusions. Increased Ck expression can be associated with the reactive proliferation of the epithelium and increasing resistance of the oral mucosa during the initial phases of radiotherapy.
Country: EUA
Editor: Mosby, Inc
Citation: Oral Surgery Oral Medicine Oral Pathology Oral Radiology And Endodontics. Mosby, Inc, v. 101, n. 2, n. 207, n. 213, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.tripleo.2005.03.033
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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