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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCorrelation between periodontal disease, inflammatory alterations and pre-eclampsiapt_BR
dc.contributor.authorPolitano, GTpt_BR
dc.contributor.authorPassini, Rpt_BR
dc.contributor.authorNomura, MLpt_BR
dc.contributor.authorVelloso, Lpt_BR
dc.contributor.authorMorari, Jpt_BR
dc.contributor.authorCouto, Ept_BR
unicamp.author.emailgabrielp@mpcnet.com.brpt_BR
unicamp.authorPolitano, G. T. Dent Sch Sao Leopoldo Mandic, Dept Pediat Dent, Campinas, Sao Paulo, Brazilpt_BR
unicamp.authorPassini, R. Nomura, M. L. Couto, E. Univ Estadual Campinas, Dept Obstet & Gynecol, Campinas, Sao Paulo, Brazilpt_BR
unicamp.authorVelloso, L. Morari, J. Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, Campinas, Sao Paulo, Brazilpt_BR
dc.subjectperiodontal diseasept_BR
dc.subjectcytokinept_BR
dc.subjectRNApt_BR
dc.subject.wosNecrosis-factor-alphapt_BR
dc.subject.wosPregnant-womenpt_BR
dc.subject.wosTnf-alphapt_BR
dc.subject.wosBlood-pressurept_BR
dc.subject.wosPlasma-levelspt_BR
dc.subject.wosRisk-factorpt_BR
dc.subject.wosIl-6pt_BR
dc.subject.wosInfectionpt_BR
dc.subject.wosCytokinespt_BR
dc.subject.wosInterleukin-1-betapt_BR
dc.description.abstractBackground and Objective: Several studies have hypothesized that periodontal disease may increase the risk of pre-eclampsia. The correlation between the two diseases would probably be based on hypertension-related cytokine release in the local periodontal environment. The aim of this study was to evaluate the association between periodontal disease and pre-eclampsia, and the correlation of the two conditions with interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) mRNA expression. Material and Methods: A case-control analysis of 116 pregnant women, 58 with pre-eclampsia (cases) and 58 normotensive pregnant women (controls) was performed. In addition to collection of socio-demographic data and periodontal evaluation, peripheral blood samples were collected for laboratory analysis of IL-6 and TNF alpha mRNA expression by real-time PCR. Results: There was an association between periodontitis and pre-eclampsia (adjusted odds ratio 3.73; 95% confidence interval 1.32-10.58). Increased TNF alpha mRNA expression was observed in pre-eclamptic women; however, there was no correlation between periodontitis and systemic cytokine expression. In the case group, systemic cytokine mRNA levels were similar in pregnant women with and without periodontitis (means +/- SD): 0.73 +/- 0.24 vs. 0.82 +/- 0.38 for TNF alpha and 1.31 +/- 1.49 vs. 1.09 +/- 0.74 for IL-6, respectively. Conclusion: Periodontitis was clinically related to pre-eclampsia; however, the supposed mechanism that correlates the two diseases, i.e. a systemic inflammatory process involving cytokines TNF alpha and IL-6 in the presence of periodontal disease, could not be confirmed in this study.pt
dc.relation.ispartofJournal Of Periodontal Researchpt_BR
dc.relation.ispartofabbreviationJ. Periodont. Res.pt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2011pt_BR
dc.date.monthofcirculationAUGpt_BR
dc.identifier.citationJournal Of Periodontal Research. Wiley-blackwell, v. 46, n. 4, n. 505, n. 511, 2011.pt_BR
dc.language.isoenpt_BR
dc.description.volume46pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage505pt_BR
dc.description.lastpage511pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0022-3484pt_BR
dc.identifier.wosidWOS:000293018900013pt_BR
dc.identifier.doi10.1111/j.1600-0765.2011.01368.xpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2007/58124-6]pt
dc.date.available2014-07-30T14:02:43Z
dc.date.available2015-11-26T16:42:38Z-
dc.date.accessioned2014-07-30T14:02:43Z
dc.date.accessioned2015-11-26T16:42:38Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57266
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57266-
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