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Type: Artigo de periódico
Title: Contribution of nuclear texture analysis for the differential diagnosis of follicular lesions of the thyroid: comparison to immunohistochemical markers
Author: Ferreira, RC
Ward, LS
Adam, RL
Leite, NJ
Metze, K
de Matos, PS
Abstract: Objective and methods: To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. Results: HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric and texture variables were useful in the discrimination of the different types of follicular lesions. Among these variables, r(2), a parameter related to the granularity of the nucleus presented the best accuracy, sensitivity, specificity and positive and negative predictive values, distinguishing benign from malignant lesions. Conclusion: The morphometric analysis of nuclear chromatin images may add accuracy to the differential diagnosis of follicular patterned lesions. Arq Bras Endocrinol Metab. 2009;53(7):804-10.
Subject: Thyroid
differential diagnosis
Country: Brasil
Editor: Sbem-soc Brasil Endocrinologia & Metabologia
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. Sbem-soc Brasil Endocrinologia & Metabologia, v. 53, n. 7, n. 804, n. 810, 2009.
Rights: aberto
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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