Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/56557
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMetabolic Profiling of Human Blood Serum from Treated Patients with Bipolar Disorder Employing H-1 NMR Spectroscopy and Chemometricspt_BR
dc.contributor.authorSussulini, Apt_BR
dc.contributor.authorPrando, Apt_BR
dc.contributor.authorMaretto, DApt_BR
dc.contributor.authorPoppi, RJpt_BR
dc.contributor.authorTasic, Lpt_BR
dc.contributor.authorBanzato, CEMpt_BR
dc.contributor.authorArruda, MAZpt_BR
unicamp.author.emailzezzi@iqm.unicamp.brpt_BR
unicamp.authorSussulini, Alessandra Zezzi Arruda, Marco Aurelio Univ Estadual Campinas, UNICAMP, Inst Chem, Grp Spectrometry Sample Preparat & Mechanizat GEP, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorSussulini, Alessandra Maretto, Danilo Althmann Poppi, Ronei Jesus Zezzi Arruda, Marco Aurelio Univ Estadual Campinas, UNICAMP, Inst Chem, Natl Inst Sci & Technol Bioanalyt, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorPrando, Alessandra Tasic, Ljubica Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorPrando, Alessandra Tasic, Ljubica Univ Estadual Campinas, UNICAMP, Inst Chem, Natl Inst Sci & Technol Struct Biol & Bioimaging, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorMaretto, Danilo Althmann Poppi, Ronei Jesus Univ Estadual Campinas, UNICAMP, Inst Chem, Chemometr Lab Analyt Chem, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorMuller Banzato, Claudio Eduardo Univ Estadual Campinas, Dept Psychiat, Fac Med Sci, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subject.wosMagnetic-resonance-spectroscopypt_BR
dc.subject.wosCholesterol Levelspt_BR
dc.subject.wosLithiumpt_BR
dc.subject.wosSchizophreniapt_BR
dc.subject.wosMetabonomicspt_BR
dc.subject.wosPlasmapt_BR
dc.subject.wosBrainpt_BR
dc.subject.wosNmrpt_BR
dc.subject.wosPathophysiologypt_BR
dc.subject.wosIdentificationpt_BR
dc.description.abstractMetabolic profiling employing hydrogen nuclear magnetic resonance (H-1 NMR) spectroscopy and chemometric analysis of human blood serum samples taken from the control group (n = 25) and patients with bipolar disorder (n = 25) was performed to identify molecular changes related to the disorder and to different drug treatments: lithium (n = 15) versus other medications (n = 10). Ibis strategy showed significant potential for exploring pathophysiological and toxicological features involved in bipolar disorder. The investigated groups (control and patients with bipolar disorder under different treatments) could be distinguished according to their metabolic profiles, and the main differential metabolites found were lipids, lipid-metabolism-related molecules (acetate, choline, and myo-inositol), and some key amino acids (glutamate, glutamine). Our results suggest that some of the 24 identified metabolites may be linked to lithium- and other-medication-provoked metabolic changes or may even be directly related to the disorder. Thus, these findings may contribute to paving the way for future studies aiming at identifying potential biomarkers for bipolar disorder.pt
dc.relation.ispartofAnalytical Chemistrypt_BR
dc.relation.ispartofabbreviationAnal. Chem.pt_BR
dc.publisher.cityWashingtonpt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Chemical Socpt_BR
dc.date.issued2009pt_BR
dc.date.monthofcirculationDEC 1pt_BR
dc.identifier.citationAnalytical Chemistry. Amer Chemical Soc, v. 81, n. 23, n. 9755, n. 9763, 2009.pt_BR
dc.language.isoenpt_BR
dc.description.volume81pt_BR
dc.description.issuenumber23pt_BR
dc.description.firstpage9755pt_BR
dc.description.lastpage9763pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0003-2700pt_BR
dc.identifier.wosidWOS:000272084700036pt_BR
dc.identifier.doi10.1021/ac901502jpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-11-20T00:33:07Z
dc.date.available2015-11-26T18:08:13Z-
dc.date.accessioned2014-11-20T00:33:07Z
dc.date.accessioned2015-11-26T18:08:13Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T18:08:13Z (GMT). No. of bitstreams: 2 WOS000272084700036.pdf: 511396 bytes, checksum: 9dd458ff67202b334681e39a5e70f609 (MD5) WOS000272084700036.pdf.txt: 42101 bytes, checksum: 60c43891f7d54863fe22d8c75e9f1444 (MD5) Previous issue date: 2009en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56557pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/56557
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56557-
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