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Type: Artigo de periódico
Title: Metabolic Profiling of Human Blood Serum from Treated Patients with Bipolar Disorder Employing H-1 NMR Spectroscopy and Chemometrics
Author: Sussulini, A
Prando, A
Maretto, DA
Poppi, RJ
Tasic, L
Banzato, CEM
Arruda, MAZ
Abstract: Metabolic profiling employing hydrogen nuclear magnetic resonance (H-1 NMR) spectroscopy and chemometric analysis of human blood serum samples taken from the control group (n = 25) and patients with bipolar disorder (n = 25) was performed to identify molecular changes related to the disorder and to different drug treatments: lithium (n = 15) versus other medications (n = 10). Ibis strategy showed significant potential for exploring pathophysiological and toxicological features involved in bipolar disorder. The investigated groups (control and patients with bipolar disorder under different treatments) could be distinguished according to their metabolic profiles, and the main differential metabolites found were lipids, lipid-metabolism-related molecules (acetate, choline, and myo-inositol), and some key amino acids (glutamate, glutamine). Our results suggest that some of the 24 identified metabolites may be linked to lithium- and other-medication-provoked metabolic changes or may even be directly related to the disorder. Thus, these findings may contribute to paving the way for future studies aiming at identifying potential biomarkers for bipolar disorder.
Country: EUA
Editor: Amer Chemical Soc
Citation: Analytical Chemistry. Amer Chemical Soc, v. 81, n. 23, n. 9755, n. 9763, 2009.
Rights: fechado
Identifier DOI: 10.1021/ac901502j
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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