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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleBioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.pt_BR
dc.contributor.authorPorte, LFpt_BR
dc.contributor.authorSantin, SMOpt_BR
dc.contributor.authorChiavelli, LURpt_BR
dc.contributor.authorSilva, CCpt_BR
dc.contributor.authorFaria, TJpt_BR
dc.contributor.authorFaria, RTpt_BR
dc.contributor.authorRuiz, ALTGpt_BR
dc.contributor.authorCarvalho, JEpt_BR
dc.contributor.authorPomini, AMpt_BR
unicamp.author.emailampomini@uem.brpt_BR
unicamp.authorPorte, Leticia F. Santin, Silvana M. O. Chiavelli, Lucas U. R. Silva, Cleuza C. Pomini, Armando M. Univ Estadual Maringa, Dept Quim, BR-87020900 Maringa, Parana, Brazilpt_BR
unicamp.authorFaria, Terezinha J. Univ Estadual Londrina, Dept Quim, BR-86051990 Londrina, Parana, Brazilpt_BR
unicamp.authorFaria, Ricardo T. Univ Estadual Londrina, Dept Agron, BR-86051990 Londrina, Parana, Brazilpt_BR
unicamp.authorRuiz, Ana L. T. G. Carvalho, Joao E. Univ Estadual Campinas, UNICAMP, CPQBA, BR-13081970 Sao Paulo, Brazilpt_BR
dc.subjectMillonia flavescenspt_BR
dc.subjectFlavonept_BR
dc.subjectHuman Ovary Sarcomapt_BR
dc.subject.wosProstate-cancer Cellspt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosActivationpt_BR
dc.description.abstractThe Orchidaceae family is appreciated worldwide for the beauty of its flowers, and hundreds of species of this family occur in Brazil. Yet little is known about the potential of orchids for therapeutic application. We have investigated bioactive compounds produced by the South Brazilian orchid Miltonia flaveseens Lindl. Bioguided studies with the fungus Cladosporium herbarum allowed the identification of hydrocinnamic acid as the active antifungal compound. In addition, the chloroform fraction exhibited an interesting activity against human cancer cells, and 5,7-dihydroxy-6,4'-dimethoxyflavone isolated from this fraction was found to be active against seven human cancer cell lines, including NCl/ADR-RES ovary sarcoma, with an IC50 value of 2.6,mu g/mL. This is the first report on the cytostatic activity of this flavone against human ovary sarcoma.pt
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-a Journal Of Biosciencespt_BR
dc.relation.ispartofabbreviationZ.Naturforsch.(C)pt_BR
dc.publisher.cityTubingenpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherVerlag Z Naturforschpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJAN-FEBpt_BR
dc.identifier.citationZeitschrift Fur Naturforschung Section C-a Journal Of Biosciences. Verlag Z Naturforsch, v. 69, n. 41671, n. 46, n. 52, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume69pt_BR
dc.description.issuenumber41671pt_BR
dc.description.firstpage46pt_BR
dc.description.lastpage52pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0939-5075pt_BR
dc.identifier.wosidWOS:000336358000006pt_BR
dc.identifier.doi10.5560/ZNC.2012-0192pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundacao Araucariapt_BR
dc.description.sponsorshipUEMpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T13:52:07Z
dc.date.available2015-11-26T17:12:31Z-
dc.date.accessioned2014-07-30T13:52:07Z
dc.date.accessioned2015-11-26T17:12:31Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T13:52:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:12:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55581
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55581-
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