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Type: Artigo de periódico
Title: Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians
Author: Trevilatto, PC
Pardo, APD
Scarel-Caminaga, RM
de Brito, RB
Alvim-Pereira, F
Alvim-Pereira, CC
Probst, CM
Garlet, GP
Sallum, AW
Line, SRP
Abstract: Chronic periodontal disease (PD) is an infectious immune-inflammatory illness. Polymorphisms in IL1 genes play a role in inflammatory diseases through the modulation of cytokine levels. Objective: This study aimed to investigate the association between polymorphisms in the IL1 gene cluster and chronic periodontitis in a Brazilian population. Design: A sample of 113 subjects over 25 years (mean age 41.2) were grouped into: 44 healthy individuals, 31 subjects with moderate and 38 with severe periodontitis. DNA was obtained through a mouthwash and oral mucosa scraping. PCR-RFLP was used to identify the following polymorphisms: ILIA C - 889T (rs1800587), IL1B C - 511T (rs16944), IL1B C + 3954T (rs11436340), IL1RN intron 2 (rs2234663). Differences in the allele/genotype/haplotype frequencies were assessed by Chi-square test (p < 0.05). The risk associated with alleles, genotypes and haplotypes was calculated as odds ratio (OR) with 95% confidence intervals (CI). Results: Neither ILIA (C - 889T) nor IL1B (C + 3954T) polymorphisms was associated with chronic PD. Allele T for IL1B (C - 511T) only associated with PD in the group of blacks and mulattos. Moreover, genotype 2/2 for IL1RN (intron 2) was associated with severe PD. Conclusions: Genotype 2/2 of IL1RN for the whole Brazilian population and allele T of IL1B (C - 511T) in a subgroup of Afro-Americans and mulattos were suggested as putative risk indicators for chronic periodontitis. (C) 2010 Elsevier Ltd. All rights reserved.
Subject: Genetic susceptibility
IL-1 gene
Chronic periodontitis
Periodontal risk factor
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Archives Of Oral Biology. Pergamon-elsevier Science Ltd, v. 56, n. 1, n. 54, n. 62, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.archoralbio.2010.09.004
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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