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Type: Artigo de periódico
Title: Maspin expression in carcinoma ex pleomorphic adenoma
Author: Martins, MT
Altemani, A
Freitas, L
Araujo, VC
Abstract: Aims: To investigate the presence and distribution of the protein maspin in carcinoma ex pleomorphic adenoma (CXPA). Methods: Maspin expression was studied by means of immunohistochemistry in 16 cases of CXPA, using the labelled polymer method. Results: According to the extent of invasion, the tumours were subdivided into: intracapsular (five cases), minimally invasive (four cases), and invasive (seven cases). Twelve patients had carcinoma with only epithelial differentiation, whereas four had a malignant myoepithelial component. Non- luminal cells in the duct- like structures of the remnant pleomorphic adenoma were strongly positive for maspin, whereas only a few luminal cells were immunopositive. A few positive cells were seen in the frequent hypocellular and hyalinised areas. Maspin was abundantly expressed, mainly in non- luminal cells, in transitional areas of CXPA with only epithelial differentiation. In frankly carcinomatous areas there was a gradual decrease in maspin expression. Almost all cells were maspin positive in CXPA with a myoepithelial component. When present, luminal cells were in general negative for maspin. Conclusions: When only epithelial cells undergo malignant transformation, maspin expression is gradually lost. In cases with a myoepithelial component, maspin expression is high, and this might be related to the tumour suppressor activity attributed to this cell.
Country: Inglaterra
Editor: B M J Publishing Group
Citation: Journal Of Clinical Pathology. B M J Publishing Group, v. 58, n. 12, n. 1311, n. 1314, 2005.
Rights: fechado
Identifier DOI: 10.1136/jcp.2004.025205
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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