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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.title7,7-Dimethylaporphine Alkaloids from the Stem of Guatteriopsis friesianapt_BR
dc.contributor.authorCosta, EVpt_BR
dc.contributor.authorMarques, FApt_BR
dc.contributor.authorPinheiro, MLBpt_BR
dc.contributor.authorVaz, NPpt_BR
dc.contributor.authorDuarte, MCTpt_BR
dc.contributor.authorDelarmelina, Cpt_BR
dc.contributor.authorBraga, RMpt_BR
dc.contributor.authorMaia, BHLNSpt_BR
unicamp.authorCosta, Emmanoel Vilaca Marques, Francisco A. Vaz, Nelissa P. Sales Maia, Beatriz Helena L. N. Univ Fed Parana, Dept Quim, Ctr Politecn, BR-81531990 Curitiba, PR, Brazilpt_BR
unicamp.authorPinheiro, Maria Lucia B. Univ Fed Amazonas, Dept Quim, BR-69077000 Manaus, Amazonas, Brazilpt_BR
unicamp.authorDuarte, Marta Cristina T. Delarmelina, Camila Univ Estadual Campinas, CPQBA, BR-13140000 Campinas, SP, Brazilpt_BR
unicamp.authorBraga, Raquel M. Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subject.wosAntimicrobial Activitypt_BR
dc.subject.wosEssential Oilspt_BR
dc.description.abstractPhytochemical investigation of a methanolic extract of the stem of Guatteriopsis friesiana afforded two new 7,7-dimethylaporphine alkaloids, 6,6a-dihydrodemethoxyguadiscine (1) and guatteriopsiscine (3), together with demethoxyguadiscine (2), liriodenine (4), corypalmine (5), and coreximine (6). Their structures were elucidated on the basis of spectroscopic methods (UV, IR, EIMS, HRESIMS, 1D/2D NMR). The absolute configurations of 1 and 3 were determined. from the circular dichroism curves. The presence of 7,7-dimethylaporphine alkaloids in this species is important for the chemotaxonomy of Guatteriopsis. Antimicrobial activity of compounds 1-5 was investigated, and 4 showed activity against Rhodococcus equi, with a MIC value of 10 mu g.mL(-1).pt
dc.relation.ispartofJournal Of Natural Productspt_BR
dc.relation.ispartofabbreviationJ. Nat. Prod.pt_BR
dc.publisherAmer Chemical Socpt_BR
dc.identifier.citationJournal Of Natural Products. Amer Chemical Soc, v. 72, n. 8, n. 1516, n. 1519, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipUniversidade Federal do Amazonas (UFAM), Brazilpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundacao Araucaria, Paranapt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
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