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Type: Artigo de periódico
Title: 7,7-Dimethylaporphine Alkaloids from the Stem of Guatteriopsis friesiana
Author: Costa, EV
Marques, FA
Pinheiro, MLB
Vaz, NP
Duarte, MCT
Delarmelina, C
Braga, RM
Abstract: Phytochemical investigation of a methanolic extract of the stem of Guatteriopsis friesiana afforded two new 7,7-dimethylaporphine alkaloids, 6,6a-dihydrodemethoxyguadiscine (1) and guatteriopsiscine (3), together with demethoxyguadiscine (2), liriodenine (4), corypalmine (5), and coreximine (6). Their structures were elucidated on the basis of spectroscopic methods (UV, IR, EIMS, HRESIMS, 1D/2D NMR). The absolute configurations of 1 and 3 were determined. from the circular dichroism curves. The presence of 7,7-dimethylaporphine alkaloids in this species is important for the chemotaxonomy of Guatteriopsis. Antimicrobial activity of compounds 1-5 was investigated, and 4 showed activity against Rhodococcus equi, with a MIC value of 10 mu g.mL(-1).
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Natural Products. Amer Chemical Soc, v. 72, n. 8, n. 1516, n. 1519, 2009.
Rights: fechado
Identifier DOI: 10.1021/np800788n
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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