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Type: Artigo de periódico
Title: 1,5-asymmetric induction in boron-mediated aldol reactions of beta-alkoxy methylketones
Author: Dias, LC
de Marchi, AA
Ferreira, MAB
Aguilar, AM
Abstract: [GRAPHICS] Good levels of substrate-controlled, 1,5-syn-stereoinduction are obtained in boron-mediated aldol reactions of beta-trichloromethyl-beta-alkoxy and beta-trifluoromethyl-beta-alkoxy methylketones with achiral aldehydes, independent of the nature of the beta-alkoxy protecting group (TBS or PMB). In the case of boron aldol reactions of beta-aryl-beta-alkoxy methylketones, the 1,5-anti-adducts were obtained with high levels of diastereoselectivity only with a beta-OPMB group.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Organic Chemistry. Amer Chemical Soc, v. 73, n. 16, n. 6299, n. 6311, 2008.
Rights: fechado
Identifier DOI: 10.1021/jo8009165
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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