Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/356299
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampUmbuzeiro, Gisela de Aragão-
dc.contributor.authorunicampMorales, Daniel Alexandre-
dc.contributor.authorunicampVacchi, Francine Inforçato-
dc.contributor.authorunicampAlbuquerque, Anjaina Fernandes de-
dc.typeArtigopt_BR
dc.titleA promising Ames battery for mutagenicity characterization of new dyespt_BR
dc.contributor.authorUmbuzeiro, Gisela A.-
dc.contributor.authorMorales, Daniel A.-
dc.contributor.authorVacchi, Francine I.-
dc.contributor.authorAlbuquerque, Anjaina F.-
dc.contributor.authorSzymczyk, Malgorzata-
dc.contributor.authorSui, Xinyi-
dc.contributor.authorVinueza, Nelson-
dc.contributor.authorFreeman, Harold S.-
dc.subjectSalmonella - Análisept_BR
dc.subject.otherlanguageSalmonellapt_BR
dc.description.abstractWhen testing new products, potential new products, or their impurities for genotoxicity in the Ames test, the quantity available for testing can be a limiting factor. This is the case for a dye repository of around 98,000 substances the Max Weaver Dye Library (MWDL). Mutagenicity data on dyes in the literature, although vast, in several cases is not reliable, compromising the performance of the in silico models. In this report, we propose a strategy for the generation of high‐quality mutagenicity data for dyes using a minimum amount of sample. We evaluated 15 dyes from different chemical classes selected from 150 representative dyes of the MWDL. The purity and molecular confirmation of each dye were determined, and the microplate agar protocol (MPA) was used. Dyes were tested at the limit of solubility in single and concentration‐response experiments using seven strains without and with metabolic activation except for anthraquinone dyes which were tested with eight strains. Six dyes were mutagenic. The most sensitive was YG1041, followed by TA97a > TA98 > TA100 = TA1538 > TA102. YG7108 as well as TA1537 did not detect any mutagenic response. We concluded that the MPA was successful in identifying the mutagenicity of dyes using less than 12.5 mg of sample. We propose that dyes should be tested in a tiered approach using YG1041 followed by TA97a, TA98, and TA100 in concentration‐response experiments. This work provides additional information on the dye mutagenicity database available in the literaturept_BR
dc.relation.ispartofEnvironmental and molecular mutagenesispt_BR
dc.relation.ispartofabbreviationEnviron. mol. mutagen.pt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWileypt_BR
dc.date.issued2021-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume62pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage52pt_BR
dc.description.lastpage65pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0893-6692pt_BR
dc.identifier.eissn1098-2280pt_BR
dc.identifier.doi10.1002/em.22417pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/em.22417pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber001pt_BR
dc.description.sponsordocumentnumber2017‐19599‐0pt_BR
dc.date.available2021-02-22T20:51:18Z-
dc.date.accessioned2021-02-22T20:51:18Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2021-02-22T20:51:18Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-02-22T20:51:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/356299-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.subject.keywordAnthraquinonespt_BR
dc.subject.keywordAzo dyespt_BR
dc.identifier.source000597655700001pt_BR
dc.creator.orcid0000-0002-8623-5200pt_BR
dc.creator.orcid0000-0002-5327-7551pt_BR
dc.creator.orcid0000-0002-6268-0465pt_BR
dc.creator.orcid0000-0003-3028-0288pt_BR
dc.type.formArtigo de pesquisapt_BR
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