Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353930
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLongato, Giovanna Barbarini-
dc.contributor.authorunicampVendramini-Costa, Débora Barbosa-
dc.contributor.authorunicampSousa, Ilza Maria de Oliveira-
dc.contributor.authorunicampTinti, Sirlene Valério-
dc.contributor.authorunicampRuiz, Ana Lucia Tasca Gois-
dc.contributor.authorunicampFoglio, Mary Ann-
dc.contributor.authorunicampCarvalho, João Ernesto de-
dc.typeArtigopt_BR
dc.titleDifferent cell death responses induced by Eupomatenoid-5 in Mcf-7 and 786-0 tumor cell linespt_BR
dc.contributor.authorLongato, Giovanna Barbarini-
dc.contributor.authorFiorito, Giovanna Francisco-
dc.contributor.authorVendramini-Costa, Debora Barbosa-
dc.contributor.authorde Oliveira Sousa, Ilza Maria-
dc.contributor.authorTinti, Sirlene Valerio-
dc.contributor.authorTasca Gois Ruiz, Ana Lucia-
dc.contributor.authorVitalino de Almeida, Sinara Monica-
dc.contributor.authorRibeiro Padilha, Rafael Jose-
dc.contributor.authorFoglio, Mary Ann-
dc.contributor.authorde Carvalho, Joao Ernesto-
dc.subjectPiper regnelliipt_BR
dc.subjectApoptosept_BR
dc.subjectNecrosept_BR
dc.subject.otherlanguagePiper regnelliipt_BR
dc.subject.otherlanguageApoptosispt_BR
dc.subject.otherlanguageNecrosispt_BR
dc.description.abstractNatural products remain an important source of new drugs, including anticancer drugs. Recently, our group reported the anticancer activity of eupomatenoid-5 (eup-5), a neolignan isolated from Piper regnellii (Miq.) C. DC. var. regnellii leaves. In vitro studies demonstrated that MCF-7 (breast) and 786-0 (kidney) were among the cancer cell lines most sensitive to eup-5 treatment. The current results demonstrate that mitochondrial membrane depolarization and generation of reactive oxygen species are implicated in eup-5-mediated cytotoxic effects on these cancer cells lines. In MCF-7 cells, eup-5 led to phosphatidylserine externalization and caspase activation, whereas the same did not occur in 786-0 cells. Scanning electron microscopy revealed a reduction of microvilli density, as well as cell morphology alterations. Moreover, treated MCF-7 cells exhibited well-characterized apoptosis alterations, while treated 786-0 cells exhibited characteristics of programmed necroptosis process. These findings support the possibility that different mechanisms may be targeted by eup-5 in cell death responsept_BR
dc.relation.ispartofToxicology in vitropt_BR
dc.relation.ispartofabbreviationToxicol. in vitropt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage1026pt_BR
dc.description.lastpage1033pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0887-2333pt_BR
dc.identifier.eissn1879-3177pt_BR
dc.identifier.doi10.1016/j.tiv.2015.04.002pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0887233315000739pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2010/50232-7pt_BR
dc.date.available2021-01-13T20:40:43Z-
dc.date.accessioned2021-01-13T20:40:43Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2021-01-13T20:40:43Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-01-13T20:40:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353930-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeCentro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolaspt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.identifier.source000356981500024pt_BR
dc.creator.orcid0000-0001-5828-8957pt_BR
dc.creator.orcid0000-0001-7617-4945pt_BR
dc.creator.orcid0000-0002-3956-3199pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-0844-8702pt_BR
dc.creator.orcid0000-0001-7715-4452pt_BR
dc.creator.orcid0000-0002-6901-6815pt_BR
dc.type.formArtigopt_BR
Appears in Collections:IB - Artigos e Outros Documentos
CPQBA - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.