Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353926
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFrezza, Tarsila Ferraz-
dc.contributor.authorunicampPrado, César Corat Ribeiro-
dc.contributor.authorunicampOliveira, Claudineide Nascimento Fernandes de-
dc.contributor.authorunicampGiorgio, Selma-
dc.contributor.authorunicampDolder, Mary Anne Heidi-
dc.contributor.authorunicampJoazeiro, Paulo Pinto-
dc.contributor.authorunicampAllegretti, Silmara Marques-
dc.typeArtigopt_BR
dc.titleEffectiveness of hyperbaric oxygen for experimental treatment ofschistosomiasis mansoni using praziquantel-free and encapsulatedinto liposomes: assay in adult worms and ovipositionpt_BR
dc.contributor.authorFrezza, Tarsila Ferraz-
dc.contributor.authorSouza, Ana Luiza Ribeiro de-
dc.contributor.authorPrado, César Corat Ribeiro-
dc.contributor.authorOliveira, Claudineide Nascimento Fernandes de-
dc.contributor.authorGremião, Maria Palmira Daflon-
dc.contributor.authorGiorgio, Selma-
dc.contributor.authorDolder, Mary Anne Heidi-
dc.contributor.authorJoazeiro, Paulo Pinto-
dc.contributor.authorAllegretti, Silmara Marques-
dc.subjectPraziquantelpt_BR
dc.subject.otherlanguagePraziquantelpt_BR
dc.description.abstractThe treatment of schistosomiasis depends on a single drug: praziquantel (PZQ). However, this treatment presents limitations such as low and/or erratic bioavailability that can contribute to cases of tolerance. Improvements to the available drug are urgently needed and studies with a controlled system of drug release, like liposomes, have been gaining prominence. The present study evaluated the activity and synergy between liposomal-praziquantel (lip.PZQ) and hyperbaric oxygen therapy (HBO). Mice received doses of 60 or 100 mg/kg PZQ or lip.PZQ, 50 days post-infection, and after the treatment, were exposed to HBO (3 atmosphere absolute – ATA) for 1 h. The viability of adult worms and oviposition were analyzed, by necropsy and Kato-Katz examination performed after 15 days of treatment. A concentration of 100 mg/kg of lip.PZQ + HBO was more effective (48.0% reduction of worms, 83.3% reduction of eggs/gram of feces) and 100% of the mice had altered of oograms (indicating interruption of oviposition) compared to other treatments and to the Control group (infected and untreated). It is known that PZQ requires participation of the host immune system to complete its antischistosomal activity and that HBO is able to stimulate the immune system. The drug became more available in the body when incorporated into liposomes and, used with HBO, the HBO worked as an adjuvant. This explains the decreases of oviposition and worms recovered form hepatic portal systempt_BR
dc.relation.ispartofActa tropicapt_BR
dc.relation.ispartofabbreviationActa troppt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume150pt_BR
dc.description.firstpage182pt_BR
dc.description.lastpage189pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0001-706Xpt_BR
dc.identifier.eissn1873-6254pt_BR
dc.identifier.doi10.1016/j.actatropica.2015.07.022pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0001706X1530070Xpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-01-13T20:12:18Z-
dc.date.accessioned2021-01-13T20:12:18Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-01-13T20:12:18Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-01-13T20:12:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353926-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento Biologia Animalpt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Biologia Animalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordLiposomal-praziquantelpt_BR
dc.subject.keywordHiperbaric-oxigenpt_BR
dc.subject.keywordSchistosoma mansonipt_BR
dc.subject.keywordIn vivo assaypt_BR
dc.identifier.source000362859500028pt_BR
dc.creator.orcid0000-0002-9450-9099pt_BR
dc.creator.orcid0000-0002-4998-4333pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5685-9661pt_BR
dc.creator.orcid0000-0003-2064-2433pt_BR
dc.creator.orcid0000-0003-4726-6159pt_BR
dc.creator.orcid0000-0003-4975-3663pt_BR
dc.type.formArtigopt_BR
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