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Type: Artigo de periódico
Title: Primary myelofibrosis: risk stratification by IPSS identifies patients with poor clinical outcome
Author: Benites, Bruno Deltreggia
Lima, Carolina Silva Costa
Lorand-Metze, Irene
Delamain, Marcia Torresan
Oliveira, Gislaine Borba
Almeida, Daiane de
Souza, Carmino Antonio de
Vassallo, Jose
Pagnano, Katia Borgia Barbosa
Abstract: OBJECTIVES: To evaluate whether risk scores used to classify patients with primary myelofibrosis and JAK-2 V617F mutation status can predict clinical outcome. METHODS: A review of clinical and laboratory data from 74 patients with primary myelofibrosis diagnosed between 1992 and 2011. The IPSS and Lille scores were calculated for risk stratification and correlated with overall survival. RESULTS: A V617F JAK2 mutation was detected in 32 cases (47%), with no significant correlation with overall survival. The patients were classified according to the scores: Lille - low, 53 (73.%); intermediate, 13 (18%); and high, 5 (7%); and IPSS- low, 15 (26%); intermediate-1, 23 (32%); intermediate-2, 19 (26%); and high, 15 (31%). Those patients presenting a higher risk according to the IPSS (high and intermediate-2) had a significantly shorter overall survival relative to the low risk groups (intermediate-1 and low) (p = 0.02). CONCLUSIONS: These results emphasize the importance of the IPSS prognostic score for risk assessment in predicting the clinical outcome of primary myelofibrosis patients.
Subject: Primary Myelofibrosis
Editor: Faculdade de Medicina / USP
Citation: Clinics. Faculdade de Medicina / USP, v. 68, n. 3, p. 339-343, 2013.
Rights: aberto
Identifier DOI: 10.6061/clinics/2013(03)OA09
Date Issue: 1-Jan-2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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