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|Title:||Passion fruit peel intake decreases inflammatory response, reverts lipid peroxidation and adiposity in diet-induced obese rats|
|Author:||Vuolo, Milena Morandi|
Lima, Glaucia Carielo
Batista, Ângela Giovana
Carazin, Cinthia Baú Betim
Cintra, Dennys Esper
Prado, Marcelo Alexandre
Maróstica Júnior, Mário Roberto
|Abstract:||This study investigated Passiflora edulis peel flour (PEPF) intake and its effect against high-fat diet–induced obesity. PEPF is a source of fiber and phenolic compounds, which can decrease oxidative stress and inflammatory cytokines, both linked to chronic inflammatory response and fat deposition in obesity. Therefore, we hypothesized that PEPF intake could decrease inflammatory cytokines and oxidative stress observed in obesity, leading to decrease of fatness and chronic inflammatory response. The aims of the study were to evaluate the lipid peroxidation, the expression of antioxidants enzymes, and inflammatory parameters in obese rats. Male Sprague-Dawley rats were divided into 3 groups (n = 8 per group) according to the diets: control (based on AIN-93G), high-fat (HF, 35% fat w/w), and HF with PEPF (HFPF), and the experiment lasted for 10 weeks. PEPF showed high dietary fiber content and bioactive compounds, such as ferulic acid, and β-carotene. PEPF intake was effective in reducing body weight gain (13.31%) and total body fat (22.58%). The lipid peroxidation in the liver and adipose tissue decreased in the HFPF group compared to HF-fed animals, whereas hepatic glutathione peroxidase and glutathione reductase activity and their expressions in the liver were higher in HFPF than HF. In addition, the PEPF intake decreased inflammatory cytokines in serum. These results suggest that PEPF intake decreases oxidative stress, possibly by the increase of antioxidant enzymes expression. Furthermore, PEPF decreases inflammatory response and protects from adiposity. Then, PEPF could act as an adjuvant to control of early parameters in obesity dysfunction|
|Appears in Collections:||FEA - Artigos e Outros Documentos|
FCA - Artigos e Outros Documentos
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