Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/346583
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampShimojo, Andréa Arruda Martins-
dc.contributor.authorunicampLichy, Rafael-
dc.contributor.authorunicampRodrigues, Ana Amélia-
dc.contributor.authorunicampSantana, Maria Helena Andrade-
dc.typeArtigopt_BR
dc.titleThe crosslinking degree controls the mechanical, rheological, and swelling properties of hyaluronic acid microparticlespt_BR
dc.contributor.authorShimojo, Andréa Arruda Martins-
dc.contributor.authorPires, Aline Mara Barbosa-
dc.contributor.authorLichy, Rafael-
dc.contributor.authorRodrigues, Ana Amélia-
dc.contributor.authorSantana, Maria Helena Andrade-
dc.subjectÁcido hialurônicopt_BR
dc.subject.otherlanguageHyaluronic acidpt_BR
dc.description.abstractViscosupplements, used for treating joint and cartilage diseases, restore the rheological properties of synovial fluid, regulate joint homeostasis and act as scaffolds for cell growth and tissue regeneration. Most viscosupplements are hydrogels composed of hyaluronic acid (HA) microparticles suspended in fluid HA. These microparticles are crosslinked with chemicals to assure their stability against enzyme degradation and to prolong the action of the viscosupplement. However, the crosslinking also modifies the mechanical, swelling and rheological properties of the HA microparticle hydrogels, with consequences on the effectiveness of the application. The aim of this study is to correlate the crosslinking degree (CD) with these properties to achieve modulation of HA/DVS microparticles through CD control. Because divinyl sulfone (DVS) is the usual crosslinker of HA in viscosupplements, we examined the effects of CD by preparing HA microparticles at 1:1, 2:1, 3:1, and 5:1 HA/DVS mass ratios. The CD was calculated from inductively coupled plasma spectrometry data. HA microparticles were previously sized to a mean diameter of 87.5 µm. Higher CD increased the viscoelasticity and the extrusion force and reduced the swelling of the HA microparticle hydrogels, which also showed Newtonian pseudoplastic behavior and were classified as covalent weak. The hydrogels were not cytotoxic to fibroblasts according to an MTT (3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide) assaypt_BR
dc.relation.ispartofJournal of biomedical materials research. Part Apt_BR
dc.relation.ispartofabbreviationJ. biomed. mater. res. Apt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWileypt_BR
dc.date.issued2014-
dc.language.isoengpt_BR
dc.description.volume103pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage730pt_BR
dc.description.lastpage737pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1549-3296pt_BR
dc.identifier.eissn1552-4965pt_BR
dc.identifier.doi10.1002/jbm.a.35225pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.35225pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-08-03T12:30:42Z-
dc.date.accessioned2020-08-03T12:30:42Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-08-03T12:30:42Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-08-03T12:30:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/346583-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordMicroparticlespt_BR
dc.subject.keywordCrosslinkingpt_BR
dc.subject.keywordDivinyl sulfonept_BR
dc.subject.keywordViscosupplementspt_BR
dc.identifier.source000349101700030pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-4407-8291pt_BR
dc.creator.orcid0000-0002-2258-4911pt_BR
dc.type.formArtigo originalpt_BR
dc.description.otherSponsorshipsem informaçãopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
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