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dc.contributor.authorunicampLana, José Fábio Santos Duarte-
dc.contributor.authorunicampHuber, Stephany Cares-
dc.contributor.authorunicampSouza, Clarissa Vasconcellos de-
dc.contributor.authorunicampUrban, Aline-
dc.contributor.authorunicampOnodera, Carolina Mie Kawagosi-
dc.contributor.authorunicampAnnichino-Bizzacchi, Joyce Maria-
dc.contributor.authorunicampSantana, Maria Helena Andrade-
dc.contributor.authorunicampBelangero, William Dias-
dc.titleRandomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the kneept_BR
dc.contributor.authorLana, J. F. S. D.-
dc.contributor.authorWeglein, A.-
dc.contributor.authorSampson, S.-
dc.contributor.authorVicente, E. F-
dc.contributor.authorHuber, S. C.-
dc.contributor.authorSouza, C. V.-
dc.contributor.authorAmbach, M. A.-
dc.contributor.authorVincent, H.-
dc.contributor.authorUrban-Paffaro, A.-
dc.contributor.authorOnodera, C. M. K.-
dc.contributor.authorAnnichino-Bizzacchi, J. M.-
dc.contributor.authorSantana, M. H. A.-
dc.contributor.authorBelangero, W. D.-
dc.description.abstractObjective: This study aims to evaluate the clinical effects of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments for mild to moderate Osteoarthritis (OA), and also examine the potential synergistic effects of PRP in combination with HA. Research continues to emerge examining the potential therapeutic efficacy of HA and PRP as autologous injectable treatments for joint arthritis. However, there is a paucity of research investigating the effects of combining HA and PRP on pain and functional status in patients with OA. Design: In this multicenter, randomized, controlled, double blind, prospective trial, 105 patients with mild to moderate knee osteoarthritis who met the study criteria were randomly allocated to one of three interventions: HA (n=36), PRP (n=36), or HA+PRP (n=33). Each patient received 3 intaarticular knee injections of their assigned substance, with 2 week intervals between each injection. Clinical outcomes were evaluated using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Visual Analogue Scale (VAS) questionnaire at baseline and after 1,3,6, and 12 months. Results: The study showed that the PRP group have significant reduction in VAS scores at 1 (p= 0.003), 3 (p= 0.0001), 6 (p= 0.0001) and 12 (p= 0.000) months when compared to HA. In addition, the PRP group illustrated greater improvement in WOMAC physical activity scale at 12 months (p= 0.008) when compared to the HA group. Combining HA and PRP resulted in a significant decreases in pain (p=0.0001) and functional limitation (p=0.0001) when compared to HA alone at 1 year post treatment; and significantly increased physical function at 1 (p=0.0004) and 3 (p=.011) months when compared to PRP alone. Conclusion: The findings of the study support the use of autologous PRP as an effective treatment of mild to moderate knee osteoarthritis. It also shows that the combination of HA and PRP resulted to better outcomes than HA alone up to 1 year and PRP alone up to 3 months. Furthermore, the results suggest that combination of PRP and HA could potentially provide better functional outcomes in the first 30 days after treatment with both PRP and HA alonept_BR
dc.relation.ispartofJournal of stem cells and regenerative medicinept_BR
dc.publisherGN Corporation Co.pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.provenanceSubmitted by Sanches Olivia ( on 2020-07-30T14:24:40Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-07-30T14:24:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.departmentDepartamento de Ortopedia e Traumatologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHyaluronic acidpt_BR
dc.subject.keywordJoint pathologypt_BR
dc.subject.keywordPlatelet-rich plasmapt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo originalpt_BR
dc.description.otherSponsorshipsem informaçãopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
FEQ - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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