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|Title:||High-throughput continuous production of liposomes using hydrodynamic flow-focusing microfluidic devices|
Oliveira, Davi Rocha Bernardes
Furtado, Guilherme de Figueiredo
de la Torre, Lucimara Gaziola
Cunha, Rosiane Lopes
|Abstract:||The microfluidic hydrodynamic flow-focusing is a simple technique for nanoscale liposome formation that provides several advantages compared to the traditional manufacturing techniques. This work aimed to perform a systematic study of the liposome formation using planar microfluidic devices with different channel aspect-ratios, as an alternative to enhance the throughput of liposome synthesis. In general, liposomes with a low polydispersity and a precise control of the size were successfully produced from alteration of the flow rate ratio and channel aspect-ratio. The higher aspect-ratio enabled the most rapid generation of liposomes with similar diameter and significant lower polydispersity index than the obtained by other batch technique. Besides, β-carotene was successfully incorporated into liposomes with efficiency of approximately 60% and the incorporation ability was not specific to a choice of microfluidic device aspect-ratio. The results suggest that the use of microfluidic devices could be employed for liposome production with a possible advantage to minimize the degree of parallelization of processes. These results demonstrate the potential technical feasibility of microfluidic processes for future industrial applications|
|Appears in Collections:||FEA - Artigos e Outros Documentos|
FEQ - Artigos e Outros Documentos
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