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Type: Artigo
Title: Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels
Author: Simão, Andressa Renatta
Fragal, Vanessa H.
Pellá, Michelly Cristina Galdioli
Garcia, Francielle P.
Nakamura, Celso V.
Silva, Rafael
Tambourgi, Elias B.
Rubira, Adley F.
Abstract: This study compared the controlled release of two drugs: vitamin-B12, and l-dopa from hydrogels based on 50% of casein (CAS, a protein), 50% of chondroitin sulfate (CS, a polysaccharide) and different amounts of SiO2. The results indicated that the incorporation of 5% of SiO2 to the materials, allowed the best organization, distribution, and diameter of the pores, which are responsible for ensuring a more controlled release. Also, the matrices were not efficient in releasing vitamin-B12, but it successfully released l-dopa. It happened because vitamin-B12 is highly hydrophilic, interacting more with the medium than with the CAS/CS matrix, while l-dopa is less polar than vitamin-B12, interacting more with the CAS/CS matrix. It is worth mentioning that all synthesized hydrogels were non-toxic to the cells as showed by the in vitro assay. This work also demonstrated the importance of evaluating drug delivery devices using drugs of different polarities before stating if they are efficient or not
Subject: Caseina
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.ijbiomac.2020.04.179
Date Issue: 2020
Appears in Collections:FEQ - Artigos e Outros Documentos

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