Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342386
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRodrigues da Silva, Gustavo Henrique-
dc.contributor.authorunicampGeronimo, Gabriela-
dc.contributor.authorunicampRibeiro, Lígia Nunes de Morais-
dc.contributor.authorunicampGuilherme Damasio, Viviane Aparecida-
dc.contributor.authorunicampMoura, Ludmilla David de-
dc.contributor.authorunicampBombeiro, André Luis-
dc.contributor.authorunicampOliveira, Juliana Damasceno-
dc.contributor.authorunicampBreitkreitz, Márcia Cristina-
dc.contributor.authorunicampPaula, Eneida de-
dc.typeArtigopt_BR
dc.titleInjectable in situ forming nanogel: a hybrid Alginate-NLC formulation extends bupivacaine anesthetic effectpt_BR
dc.contributor.authorRodrigues da Silva, G.H.-
dc.contributor.authorGeronimo, G.-
dc.contributor.authorRibeiro, L.N.M.-
dc.contributor.authorGuilherme, V.A.-
dc.contributor.authorde Moura, L.D.-
dc.contributor.authorBombeiro, A.L.-
dc.contributor.authorOliveira, J.D.-
dc.contributor.authorBreitkreitz, M.C.-
dc.contributor.authorde Paula, E.-
dc.subjectBiopolímerospt_BR
dc.subjectMateriais nanoestruturadospt_BR
dc.subject.otherlanguageBiopolymerspt_BR
dc.subject.otherlanguageNanostructured materialspt_BR
dc.description.abstractFinding an ideal anesthetic agent for postoperative pain control, with long action and low side effects, is still a challenge. Local anesthetics have potential for such application if their time of action is improved. This work introduces a new hybrid formulation formed by the association of a nanostructured lipid carrier with a biopolymeric system to encapsulate bupivacaine (BVC). The hybrid formulation was physicochemical and structurally characterized by DLS, TEM, DSC, XRD and FTIR-ATR, and it remained stable for 12 months at room temperature. In vivo analgesia and imaging tests showed that the hybrid system was able to modulate the release, and to increase the concentration of BVC at the site of action, by forming a nanogel in situ. Such nanogel improved over 5 times (>24 h) the anesthesia duration, when compared to free BVC at clinical (0.5%) doses. Therefore, this novel in situ-forming nanogel shows great potential to be used in postsurgical pain control, improving the action of BVC, without losing its versatility of (infiltrative) applicationpt_BR
dc.relation.ispartofMaterials science and engineering C: materials for biological applicationspt_BR
dc.relation.ispartofabbreviationMater. sci. eng. C: mater. biol. appl.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2020-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume109pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn0928-4931pt_BR
dc.identifier.eissn1873-0191pt_BR
dc.identifier.doi10.1016/j.msec.2019.110608pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0928493119328978pt_BR
dc.date.available2020-06-01T19:21:10Z-
dc.date.accessioned2020-06-01T19:21:10Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-06-01T19:21:10Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-06-01T19:21:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342386-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Analíticapt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordControlled drug deliverypt_BR
dc.subject.keywordHybrid formulationspt_BR
dc.identifier.source2-s2.0-85077028362pt_BR
dc.creator.orcid0000-0001-7377-8532pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-6097-5449pt_BR
dc.creator.orcid0000-0002-1008-2906pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2303-8127pt_BR
dc.creator.orcid0000-0002-0999-9303pt_BR
dc.creator.orcid0000-0002-0596-9692pt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid110608pt_BR
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