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Type: Artigo
Title: Injectable in situ forming nanogel: a hybrid Alginate-NLC formulation extends bupivacaine anesthetic effect
Author: Rodrigues da Silva, G.H.
Geronimo, G.
Ribeiro, L.N.M.
Guilherme, V.A.
de Moura, L.D.
Bombeiro, A.L.
Oliveira, J.D.
Breitkreitz, M.C.
de Paula, E.
Abstract: Finding an ideal anesthetic agent for postoperative pain control, with long action and low side effects, is still a challenge. Local anesthetics have potential for such application if their time of action is improved. This work introduces a new hybrid formulation formed by the association of a nanostructured lipid carrier with a biopolymeric system to encapsulate bupivacaine (BVC). The hybrid formulation was physicochemical and structurally characterized by DLS, TEM, DSC, XRD and FTIR-ATR, and it remained stable for 12 months at room temperature. In vivo analgesia and imaging tests showed that the hybrid system was able to modulate the release, and to increase the concentration of BVC at the site of action, by forming a nanogel in situ. Such nanogel improved over 5 times (>24 h) the anesthesia duration, when compared to free BVC at clinical (0.5%) doses. Therefore, this novel in situ-forming nanogel shows great potential to be used in postsurgical pain control, improving the action of BVC, without losing its versatility of (infiltrative) application
Subject: Biopolímeros
Materiais nanoestruturados
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.msec.2019.110608
Date Issue: 2020
Appears in Collections:IQ - Artigos e Outros Documentos
IB - Artigos e Outros Documentos

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