Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342349
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBarini, Ricardo-
dc.typeArtigopt_BR
dc.titleGestational and perinatal outcomes in recurrent miscarriages couples treated with lymphocyte immunotherapypt_BR
dc.contributor.authorSarno, M.-
dc.contributor.authorCavalcante, M.B.-
dc.contributor.authorNiag, M.-
dc.contributor.authorPimentel, K.-
dc.contributor.authorLuz, I.-
dc.contributor.authorFigueiredo, B.-
dc.contributor.authorMichelon, T.-
dc.contributor.authorNeumann, J.-
dc.contributor.authorLima, S.-
dc.contributor.authorMachado, I.N.-
dc.contributor.authorAraujo Júnior, E.-
dc.contributor.authorBarini, R.-
dc.subjectAutoanticorpospt_BR
dc.subjectImunoterapiapt_BR
dc.subject.otherlanguageAutoantibodiespt_BR
dc.subject.otherlanguageImmunotherapypt_BR
dc.description.abstractThis study aims to elucidate which types of recurrent miscarriage (RM) patients experienced a livebirth after paternal lymphocyte immunotherapy (LIT) and to evaluate the perinatal outcome. Retrospective analysis of a multicenter, observational study which enrolled 1096 couples with a history of two or more spontaneous miscarriages without any intercalated delivery. We conducted an intention-to-treat analysis of couples with RM treated with or without LIT regarding to gestational and perinatal outcomes. We compared groups by using the Student's t-test or Kruskal–Wallis test, Fisher's exact-test and χ2 test when appropriate. The success of gestation was significantly higher in the LIT group (60.1% vs. 33.1%; p < 0.001). A sub-analysis of four different immune disorder groups revealed a significantly higher success in the LIT group in all immune categories, except in patients who had autoantibodies positive. We observed no significant differences in perinatal outcomes such as gestational age at birth, preterm and extreme preterm birth, and birth weight in successful pregnancy in both groups. The success rate was significantly higher when LIT was administrated before and during pregnancy and only during pregnancy compared to only before pregnancy (p < 0.01). Careful laboratory test phenotyping of RM patients may identify subgroups most likely to benefit and exclude those with little likelihood of benefit, and LIT during a pregnancy may significantly improve success ratespt_BR
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology: Xpt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume3pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.eissn2590-1613pt_BR
dc.identifier.doi10.1016/j.eurox.2019.100036pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2590161319300717pt_BR
dc.date.available2020-06-01T15:33:57Z-
dc.date.accessioned2020-06-01T15:33:57Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-06-01T15:33:56Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-06-01T15:33:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342349-
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordRecurrent abortionpt_BR
dc.subject.keywordSpontaneous abortionpt_BR
dc.identifier.source2-s2.0-85066263690pt_BR
dc.creator.orcid0000-0002-4138-6945pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid100036pt_BR
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