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Type: Artigo
Title: High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake : protective response in metabolic disorders and liver histopathology
Author: Nogueira-Lima, Ellen
Lamas, Celina de Almeida
Baseggio, Andressa Mara
Vale, Jéssica Stephany Fernandes do
Maróstica Junior, Mário Roberto
Cagnon, Valéria Helena Alves
Abstract: Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and exhibit positive effects on metabolic disorders and hepatic lesions. Therefore, the aim of the study herein was to investigate the patented jaboticaba peel extract effects (PJE) on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate model, receiving a either normolipid diet or HFD for 8 weeks. The results showed that PJE reduced insulin resistance and glucose intolerance, decreased hepatic lipid accumulation, and inflammatory markers such as PPARγ and TNFα, respectively. In conclusion, the PJE treatment promoted protective effects in the metabolism of insulin and glucose and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight and associated with PCa
Subject: Neoplasias da próstata
Country: Estados Unidos
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.1080/01635581.2019.1684526
Date Issue: Nov-2019
Appears in Collections:IB - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

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