Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337631
Type: Artigo
Title: Sensory ataxia rating scale: Development and validation of a functional scale for patients with sensory neuronopathies
Author: Martinez, Alberto R. M.
Martins, Melina P.
Martins, Carlos R. Jr.
Faber, Ingrid
de Rezende, Thiago J. R.
Nucci, Anamarli
Franca, Marcondes C., Jr.
Abstract: Sensory neuronopathies (SN) result from dorsal root ganglia damage and manifest with a combination of sensory deficits and proprioceptive ataxia. Characterization of the natural history and development of therapeutic trials are hampered by the lack of clinical scales that capture the whole spectrum of SN-related manifestations. We propose and validate a rating instrument for SN. Three experienced neuromuscular specialists developed items to rate SN. The resultant instrument was later validated by the assessment of the intra-class correlation coefficient, for inter-rater validity in 48 SN patients, and later in a smaller subset of 16 patients to assess its intra-rater validity. Standardized Crombach's alpha and Oblimin rotation analysis were performed to verify internal consistency and items' relationship, respectively. Evaluation of Sensory Ataxia Rating Scale (SEARS)'s external validity was performed by comparison to: scale for the assessment and rating of ataxia (SARA), Beck balance scale (BBS), and INCAT sensory sum score (ISS). A 10-item scale with an intra-class correlation coefficient >0.95 for intra- and inter-rating measurements with a good internal consistency (standardized Cronbach's alpha of 0.83) were observed. There was a normal distribution of the scores without a floor or ceiling effect. A moderate to good correlation between SEARS and SARA, BBS, and ISS was observed. SEARS is a reliable, easy-to-perform and consistent instrument to rate SN. Larger cohorts and multicenter studies are needed to validate its usefulness towards possible treatment trials.
Subject: Atrofia Muscular
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/jns.12330
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/jns.12330
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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