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Type: Artigo
Title: In vitro SPF and photostability assays of emulsion containing nanoparticles with vegetable extracts rich in flavonoids
Author: Cefali, Leticia Caramori
Ataide, Janaina Artem
Eberlin, Samara
Gonçalves, Fernanda Cristina da Silva
Fernandes, Ana Rita
Marto, Joana
Ribeiro, Helena Margarida
Foglio, Mary Ann
Mazzola, Priscila Gava
Souto, Eliana Barbosa
Abstract: The aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L.) were produced and characterized for their morphology, mean particle size, zeta potential, and encapsulation efficiency. A final topical formulation was obtained by dispersing chitosan/TPP nanoparticles in an o/w emulsion. Results showed that nanoparticles dispersion exhibited yellowish color, spherical shape, and uniform appearance. Extract-loaded chitosan/TPP nanoparticles showed a mean particle size of 557.11 +/- 3.1nm, polydispersity index of 0.39 +/- 0.27, zeta potential of +11.54 +/- 2.1mV, and encapsulation efficiency of 75.89% of rutin. The recorded texture parameters confirm that the developed formulation is appropriate for skin application. The SPF obtained was 2.3 +/- 0.4, with a critical wavelength of 387.0nm and 0.69 UVA/UVB ratio. The developed formulation exhibited photostability, allowing the release of flavonoids from nanoparticles while retaining rutin into the skin in a higher extension
Subject: Nanopartículas
Protetores solares
Country: Estados Unidos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1208/s12249-018-1217-7
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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