Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337429
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampJacob, Priscila Lima-
dc.contributor.authorunicampSartorato, Edi Lúcia-
dc.typeArtigopt_BR
dc.titleContribution of the GSTP1 c.313A > G variant to hearing loss risk in patients exposed to platin chemotherapy during childhoodpt_BR
dc.contributor.authorLiberman, P. H. P.-
dc.contributor.authorGoffi-Gomez, M. V. S.-
dc.contributor.authorSchultz, C.-
dc.contributor.authorJacob, P. L.-
dc.contributor.authorde Paula, C. A. A.-
dc.contributor.authorSartorato, E. L.-
dc.contributor.authorTorrezan, G. T.-
dc.contributor.authorFerreira, E. N.-
dc.contributor.authorCarraro, D. M.-
dc.subjectCarboplatinapt_BR
dc.subject.otherlanguageCarboplatinpt_BR
dc.description.abstractOtotoxicity is a potential adverse effect of chemotherapy with platin drugs, such as cisplatin and carboplatin, in children. Hearing loss (HL) affecting frequencies below 4kHz can compromise speech perception. The aim of this study was to investigate whether genetic variants previously implicated in ototoxicity are associated with HL overall and HL below 4kHz in pediatric oncology patients treated with cisplatin or carboplatin.Materials and methodsPatients given cisplatin or carboplatin for a pediatric cancer at least 5years prior to the start of the study were enrolled. The patients underwent comprehensive audiological evaluations and genotyping to detect the presence of the GJB2 c.35delG, GSTP1 c.313A>G, and MT-RNR1m.1555A>G polymorphisms.ResultsHL was identified in 31/61 patients (50.8%), including 28/42 treated with cisplatin (66.6%) and 3/19 treated with carboplatin (15.8%). HL was associated with higher mean doses of cisplatin (p=.002) and carboplatin (p=.010). The c.313A>G variant of GSTP1 (heterozygous or homozygous) was detected in 31/61 patients (50.8%). An association between this variant allele and HL involving frequencies 4kHz was identified (p=.020; 10-fold vs. non-carriers). No associations with HL were observed for GJB2 or MT-RNR1 gene variants.ConclusionThe GSTP1 c.313A>G variant may increase the risk of low-frequency HL in pediatric oncology patients treated with cisplatin or carboplatin chemotherapypt_BR
dc.relation.ispartofClinical and translational oncologypt_BR
dc.publisher.cityMilanpt_BR
dc.publisher.countryItáliapt_BR
dc.publisherSpringerpt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage630pt_BR
dc.description.lastpage635pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1699-048Xpt_BR
dc.identifier.eissn1699-3055pt_BR
dc.identifier.doi10.1007/s12094-018-1964-7pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12094-018-1964-7pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-03-26T00:41:00Z-
dc.date.accessioned2020-03-26T00:41:00Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-03-26T00:41:00Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-26T00:41:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337429-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeCentro de Biologia Molecular e Engenharia Genéticapt_BR
dc.contributor.unidadeCentro de Biologia Molecular e Engenharia Genéticapt_BR
dc.subject.keywordHearing losspt_BR
dc.subject.keywordCancerpt_BR
dc.subject.keywordOtotoxicitypt_BR
dc.subject.keywordCisplatinpt_BR
dc.subject.keywordGSTP1pt_BR
dc.identifier.source000468081500010pt_BR
dc.creator.orcid0000-0003-0701-6075pt_BR
dc.creator.orcid0000-0002-2000-0118pt_BR
dc.type.formArtigo de pesquisapt_BR
dc.description.otherSponsorshipsem informaçãopt_BR
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