Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337426
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampReginato, Andressa-
dc.contributor.authorunicampMilanski, Marciane-
dc.typeArtigopt_BR
dc.titleNeonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intakept_BR
dc.contributor.authorPinheiro, Isabeli Lins-
dc.contributor.authorda Silva, Aline Isabel-
dc.contributor.authorReginato, Andressa-
dc.contributor.authorda Silva Filho, Reginaldo Correia-
dc.contributor.authorMonteiro Galindo, Ligia Cristina-
dc.contributor.authorBarbosa Matos, Rhowena Jane-
dc.contributor.authorde Souza Ferraz Junior, Jose Candido-
dc.contributor.authorMeneses da Silva Castro, Ana Elisa Toscano-
dc.contributor.authorFerreira, Marciane Milanski-
dc.contributor.authorde Castro, Raul Manhaes-
dc.contributor.authorde Souza, Sandra Lopes-
dc.subjectSerotoninapt_BR
dc.subjectPlasticidade fenotípicapt_BR
dc.subject.otherlanguageSerotoninpt_BR
dc.subject.otherlanguagePhenotypic plasticitypt_BR
dc.description.abstractThe neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and citalopram, blocking serotonin transporter (SERT) at the presynaptic neuron, which regulates extracellular 5-HT levels. Evidence suggests that the exposure to SSRIs in the neurodevelopmental period may alters 5-HT signaling sensitivity on food intake control. The aim of the present study was to evaluate the effects of neonatal exposure to fluoxetine on molecular and cellular components of the serotonergic system and food intake control in young animals. Methods: The animals were divided according to experimental manipulation, Fluoxetine Group (FG): male pups received application of fluoxetine (10 mg/kg, 10 mu L/g) and Saline Group (SG): male pups received saline application (0.9% NaCl, 10 mu L/g), both throughout lactation (PND1-PND21). They evaluated body weight, food intake, SERT gene and protein expression, serotonin content in the hypothalamus. The neonatal exposure to fluoxetine promoted reduction in body weight, disturb the serotonin hypophagic response, and increase the serotonin and SERT hypothalamic in young animals. We conclude that the changes of components of the serotonergic system by neonatal exposure to fluoxetine may be responsible for disturb the inhibitory action of serotonin on food intakept_BR
dc.relation.ispartofBehavioural Brain Researchpt_BR
dc.relation.ispartofabbreviationBehav Brain Respt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume357pt_BR
dc.description.firstpage65pt_BR
dc.description.lastpage70pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0166-4328pt_BR
dc.identifier.eissn1872-7549pt_BR
dc.identifier.doi10.1016/j.bbr.2017.07.038pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0166432817302681?via%3Dihubpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.date.available2020-03-26T00:13:34Z-
dc.date.accessioned2020-03-26T00:13:34Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-03-26T00:13:34Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-26T00:13:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337426-
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.subject.keywordSelective serotonin reuptake inhibitors (SSRIs)pt_BR
dc.subject.keywordSerotonin transporter (SEAT)pt_BR
dc.subject.keywordLactationpt_BR
dc.identifier.source455422200009pt_BR
dc.creator.orcid0000-0001-6408-7000pt_BR
dc.creator.orcid0000-0002-6322-5368pt_BR
dc.type.formArtigo de pesquisapt_BR
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