Please use this identifier to cite or link to this item:
Type: Artigo
Title: Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake
Author: Pinheiro, Isabeli Lins
da Silva, Aline Isabel
Reginato, Andressa
da Silva Filho, Reginaldo Correia
Monteiro Galindo, Ligia Cristina
Barbosa Matos, Rhowena Jane
de Souza Ferraz Junior, Jose Candido
Meneses da Silva Castro, Ana Elisa Toscano
Ferreira, Marciane Milanski
de Castro, Raul Manhaes
de Souza, Sandra Lopes
Abstract: The neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and citalopram, blocking serotonin transporter (SERT) at the presynaptic neuron, which regulates extracellular 5-HT levels. Evidence suggests that the exposure to SSRIs in the neurodevelopmental period may alters 5-HT signaling sensitivity on food intake control. The aim of the present study was to evaluate the effects of neonatal exposure to fluoxetine on molecular and cellular components of the serotonergic system and food intake control in young animals. Methods: The animals were divided according to experimental manipulation, Fluoxetine Group (FG): male pups received application of fluoxetine (10 mg/kg, 10 mu L/g) and Saline Group (SG): male pups received saline application (0.9% NaCl, 10 mu L/g), both throughout lactation (PND1-PND21). They evaluated body weight, food intake, SERT gene and protein expression, serotonin content in the hypothalamus. The neonatal exposure to fluoxetine promoted reduction in body weight, disturb the serotonin hypophagic response, and increase the serotonin and SERT hypothalamic in young animals. We conclude that the changes of components of the serotonergic system by neonatal exposure to fluoxetine may be responsible for disturb the inhibitory action of serotonin on food intake
Subject: Serotonina
Plasticidade fenotípica
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.bbr.2017.07.038
Date Issue: 2019
Appears in Collections:FCA - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.