Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/336448
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPeres, Raquel Mary Rodrigues-
dc.contributor.authorunicampCarvalho, Benilton de Sá-
dc.contributor.authorunicampConz, Livia-
dc.contributor.authorunicampCardoso Filho, Cassio-
dc.contributor.authorunicampRamalho, Susana Oliveira Botelho-
dc.contributor.authorunicampSilva, Geisilene Russano de Paiva-
dc.contributor.authorunicampDerchain, Sophie Françoise Mauricette-
dc.contributor.authorunicampLopes-Cendes, Íscia Teresinha-
dc.contributor.authorunicampSarian, Luís Otávio Zanatta-
dc.typeArtigopt_BR
dc.titleCopy number alterations associated with clinical features in an underrepresented population with breast cancerpt_BR
dc.contributor.authorRodrigues‐Peres, Raquel M.-
dc.contributor.authorCarvalho, Benilton de S.-
dc.contributor.authorAnurag, Meenakshi-
dc.contributor.authorLei, Jonathan T.-
dc.contributor.authorConz, Livia-
dc.contributor.authorGonçalves, Rodrigo-
dc.contributor.authorCardoso Filho, Cássio-
dc.contributor.authorRamalho, Susana-
dc.contributor.authorPaiva, Geisilene R. de-
dc.contributor.authorDerchain, Sophie F. M.-
dc.contributor.authorLopes‐Cendes, Iscia-
dc.contributor.authorEllis, Matthew J.-
dc.contributor.authorSarian, Luis O.-
dc.subjectNeoplasias da mamapt_BR
dc.subjectAdenocarcinoma mucinosopt_BR
dc.subjectDiagnóstico clínicopt_BR
dc.subject.otherlanguageBreast neoplasmspt_BR
dc.subject.otherlanguageAdenocarcinomapt_BR
dc.subject.otherlanguageMucinouspt_BR
dc.subject.otherlanguageClinical diagnosispt_BR
dc.description.abstractAs the most incident tumor among women worldwide, breast cancer is a heterogeneous disease. Tremendous efforts have been made to understand how tumor characteristics as histological type, molecular subtype, and tumor microenvironment collectively influence disease diagnosis to treatment, which impact outcomes. Differences between populations and environmental and cultural factors have impacts on the origin and evolution of the disease, as well as the therapeutic challenges that arise due to these factors. We, then, compared copy number variations (CNVs) in mucinous and nonmucinous luminal breast tumors from a Brazilian cohort to investigate major CNV imbalances in mucinous tumors versus non‐mucinous luminal tumors, taking into account their clinical and pathological features.48 breast tumor samples and 48 matched control blood samples from Brazilian women were assessed for CNVs by chromosome microarray. Logistic regression and random forest models were used in order to assess CNVs in chromosomal regions from tumors.CNVs that were identified in chromosomes 1, 5, 8, 17, 19, and 21 classify tumors according to their histological type, ethnicity, disease stage, and familial history.Copy number alterations described in this study provide a better understanding of the landscape of genomic aberrations in mucinous breast cancers that are associated with clinical features.pt_BR
dc.relation.ispartofMolecular genetics and genomic medicinept_BR
dc.relation.ispartofabbreviationMol. genet. genomic. med.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2019-07-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume7pt_BR
dc.description.issuenumber7pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2324-9269pt_BR
dc.identifier.doi10.1002/mgg3.750pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/mgg3.750pt_BR
dc.description.sponsorshipFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulopt_BR
dc.description.sponsordocumentnumber2013/25683-3; 2015/18830-5pt_BR
dc.date.available2020-03-13T13:15:44Z-
dc.date.accessioned2020-03-13T13:15:44Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-03-13T13:15:44Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T13:45:09Z : No. of bitstreams: 1 000475675000002.pdf: 643549 bytes, checksum: d48b7a50643869b70421e12dd45045d4 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-13T13:15:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/336448-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.departmentDepartamento de Genética Médicapt_BR
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Matemática Estatística e Ciência da Computaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordCopy number alterationpt_BR
dc.subject.keywordEthnicitypt_BR
dc.subject.keywordFamily historypt_BR
dc.subject.keywordMucinouspt_BR
dc.subject.keywordStagept_BR
dc.identifier.source000475675000002pt_BR
dc.creator.orcid0000-0002-5855-6859pt_BR
dc.creator.orcid0000-0001-5122-5646pt_BR
dc.creator.orcid0000-0002-8277-3554pt_BR
dc.creator.orcid0000-0002-1895-0106pt_BR
dc.creator.orcid0000-0002-5485-0970pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-1029-9993pt_BR
dc.creator.orcid0000-0002-6221-6822pt_BR
dc.creator.orcid0000-0002-9554-6131pt_BR
dc.type.formArtigo originalpt_BR
dc.identifier.articleide00750pt_BR
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