Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/336427
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSanches, Bruno Domingos Azevedo-
dc.contributor.authorunicampCarvalho, Hernandes Faustino de-
dc.contributor.authorunicampMaldarine, Juliana dos Santos-
dc.contributor.authorunicampTaboga, Sebastião Roberto-
dc.typeArtigopt_BR
dc.titleDifferences between male and female prostates in terms of physiology, sensitivity to chemicals and pathogenesis-A review in a rodent modelpt_BR
dc.contributor.authorSanches, Bruno D. A.-
dc.contributor.authorCarvalho, Hernandes F.-
dc.contributor.authorMaldarine, Juliana S.-
dc.contributor.authorBiancardi, Manoel F.-
dc.contributor.authorSantos, Fernanda C. A.-
dc.contributor.authorVilamaior, Patricia S. L.-
dc.contributor.authorTaboga, Sebastiao R.-
dc.subjectProgesteronapt_BR
dc.subject.otherlanguageProgesteronept_BR
dc.description.abstractThe prostate is a gland that is not exclusively present in males, being also found in females of several mammalian species, including humans. There is evidence that the prostate in both sexes is affected by the same pathologies such as prostatitis, benign alterations and even cancer. In view of the difficulties of manipulating the prostate gland, the Mongolian gerbil (Meriones unguiculatus), a rodent species with high incidence of functional prostates in females, is widely used in studies of the female prostate. However, despite knowing much about the similarities between the female and male prostate, little emphasis has been placed on the differences between them. This review investigates the intersex differences in prostate development, physiology and pathogenesis. The female prostate develops earlier than in males and studies indicate that it is more sensitive to oestrogens than the male prostate, as well as being more sensitive to exposure to xenoestrogens, such as Bisphenol A and methylparaben, with a higher susceptibility to benign lesions in the adult and senile prostate than in males. In addition, the female prostate is impacted by pregnancy and the oestrous cycle, and is also dependent on progesterone. The peculiarities of the female prostate raise concerns about the risk of it undergoing neglected changes as a result of environmental chemicals, since safe dosages are established exclusively for the male prostatept_BR
dc.relation.ispartofCell biology internationalpt_BR
dc.relation.ispartofabbreviationCell biol. int.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2020-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume44pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage27pt_BR
dc.description.lastpage35pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1065-6995pt_BR
dc.identifier.eissn1095-8355pt_BR
dc.identifier.doi10.1002/cbin.11214pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/cbin.11214pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível Superiorpt_BR
dc.description.sponsorshipCNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulopt_BR
dc.description.sponsordocumentnumber442630/2014‐0; 305840/2015‐0pt_BR
dc.description.sponsordocumentnumber2009/16150‐6; 2014/26660‐0; 2018/23383‐6pt_BR
dc.description.sponsordocumentnumber88887.302469/2018‐00pt_BR
dc.date.available2020-03-13T12:16:48Z-
dc.date.accessioned2020-03-13T12:16:48Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-03-13T12:16:48Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T13:45:24Z : No. of bitstreams: 1 000482499500001.pdf: 2452060 bytes, checksum: eff3371e31249bbadc10339057b43e31 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-13T12:16:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/336427-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentPrograma de Pós-Graduação em Biologia Celular e Estruturalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordBPApt_BR
dc.subject.keywordEthinyloestradiolpt_BR
dc.subject.keywordFemale prostatept_BR
dc.subject.keywordMethylparabenpt_BR
dc.subject.keywordSex differencespt_BR
dc.identifier.source000482499500001pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-3080-9447pt_BR
dc.creator.orcid0000-0003-0604-1703pt_BR
dc.creator.orcid0000-0002-0970-4288pt_BR
dc.type.formArtigo de Revisãopt_BR
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