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Type: Artigo
Title: Proteomics And Molecular Tools For Unveiling Missing Links In The Biochemical Understanding Of Schizophrenia
Author: Nascimento
Juliana M.; Garcia
Sheila; Saia-Cereda
Veronica M.; Santana
Aline G.; Brandao-Teles
Caroline; Zuccoli
Giuliana S.; Junqueira
Danielle G.; Reis-de-Oliveira
Guilherme; Baldasso
Paulo A.; Cassoli
Juliana S.; Martins-de-Souza
Abstract: Psychiatric disorders are one of the biggest burdens to society, with significant personal and economical costs. Schizophrenia (SCZ), among them, is still poorly understood, and its molecular characterization is crucial to improve patients' diagnosis and treatment. The combination of genetic, biochemical, and environmental factors leads to systemic alterations, which are yet to be fully comprehended. Thus, understanding those missing links by connecting some molecular reports of SCZ is essential. From postmortem brain to animal models and cell culture, new tools are emerging, including recent advances in proteomics, and there is a need to apply them to solve these problems. Here, we review some of those features, mainly related to where proteomics could help, and discuss whether those new technologies could and should be applied to psychiatric disorder studies.
Subject: Biomarkers
Editor: Wiley-V C H Verlag Gmbh
Citation: Proteomics Clinical Applications. Wiley-v C H Verlag Gmbh, v. 10, p. 1148 - 1158, 2016.
Rights: fechado
Identifier DOI: 10.1002/prca.201600021
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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